TENT5C Antibody

Code CSB-PA736203LA01HU
Size US$166
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Image
  • Western blot
    All lanes: TENT5C antibody at 2 μg/ml + Mouse heart tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 45 kDa
    Observed band size: 45, 35 kDa

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA736203LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA736203LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TENT5C Polyclonal antibody
Uniprot No.
Target Names
TENT5C
Alternative Names
FA46C_HUMAN antibody; Fam46c antibody; Family with sequence similarity 46 member C antibody; Protein FAM46C antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Terminal nucleotidyltransferase 5C protein (1-391AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TENT5C Antibody (Product code: CSB-PA736203LA01HU) is Non-conjugated. For TENT5C Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA736203LB01HU TENT5C Antibody, HRP conjugated ELISA
FITC CSB-PA736203LC01HU TENT5C Antibody, FITC conjugated
Biotin CSB-PA736203LD01HU TENT5C Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews
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Applications : WB

Sample type: Human Cell

Review: Immunoblot analysis in FAM46C-overexpressing OPM2 cells. Left: representative blots; right: quantification of band intensities (mean ± SEM; n = 3).

By Anonymous

Target Background

Function
Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.; (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
Gene References into Functions
  1. Study shows that FAM46C, a tumor suppressor for hepatocellular carcinoma, is important for the anti-proliferation and proapoptotic effects of norcantharidin. PMID: 28341836
  2. Reduced FAM46C mRNA expression levels were associated with Gastric Cancer. PMID: 27770343
  3. data strengthen the growing evidence that the FAM46C gene is involved in the pathogenesis of MM as a potential tumour suppressor, although its role remains to be clarified. PMID: 26456599
  4. FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of endoplasmic reticulum response transcripts. PMID: 28931820
  5. FAM46C mutation as a contributor to myeloma pathogenesis and disease progression via perturbation in plasma cell differentiation and endoplasmic reticulum homeostasis. PMID: 28619709
  6. Data indicate that when cases with FAM46C deletion or mutation were considered together, they were strongly associated with impaired overall survival (OS) in the intensive treatment setting. PMID: 21994415

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Subcellular Location
Nucleus. Cytoplasm.
Protein Families
FAM46 family
Database Links

HGNC: 24712

OMIM: 613952

KEGG: hsa:54855

STRING: 9606.ENSP00000358458

UniGene: Hs.356216

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