CIAO2A Antibody

Code CSB-PA872502LA01HU
Size US$166
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  • Western blot
    All lanes: CIAO2A antibody at 8µg/ml + NIH/3T3 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 19, 12 kDa
    Observed band size: 19 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FAM96A Polyclonal antibody
Uniprot No.
Target Names
FAM96A
Alternative Names
CIAO2A antibody; CIA2A antibody; FAM96A antibody; Cytosolic iron-sulfur assembly component 2A antibody; MIP18 family protein FAM96A antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Cytosolic iron-sulfur assembly component 2A protein (1-160AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CIAO2A Antibody (Product code: CSB-PA872502LA01HU) is Non-conjugated. For CIAO2A Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA872502LB01HU CIAO2A Antibody, HRP conjugated ELISA
FITC CSB-PA872502LC01HU CIAO2A Antibody, FITC conjugated
Biotin CSB-PA872502LD01HU CIAO2A Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation. May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1.
Gene References into Functions
  1. our data suggest that hTERTR-FAM96A may serve as an efficient anti-tumor agent for the treatment of hepatocellular carcinoma. PMID: 28443470
  2. FAM96A expression was much reduced in tumorigenic ICC-SCs. PMID: 25716227
  3. CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization. PMID: 23891004
  4. putative metal-binding site of bacterial DUF59 proteins is not conserved in Fam96a, but Fam96a interacts tightly in vitro with Ciao1, the cytosolic iron-assembly protein PMID: 22683786
Subcellular Location
Cytoplasm.
Protein Families
MIP18 family
Tissue Specificity
Substantially enriched in macrophages.
Database Links

HGNC: 26235

KEGG: hsa:84191

STRING: 9606.ENSP00000300030

UniGene: Hs.439548

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