FANCB Antibody, FITC conjugated

Code CSB-PA818751LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FANCB Polyclonal antibody
Uniprot No.
Target Names
FANCB
Alternative Names
FA2 antibody; FAAP90 antibody; FAAP95 antibody; FAB antibody; FACB antibody; Fancb antibody; FANCB_HUMAN antibody; Fanconi anemia associated polypeptide of 95 kDa antibody; Fanconi anemia group B protein antibody; Fanconi anemia; complementation group B antibody; Fanconi anemia-associated polypeptide of 95 kDa antibody; Protein FACB antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Fanconi anemia group B protein (431-574AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
DNA repair protein required for FANCD2 ubiquitination.
Gene References into Functions
  1. We identified a 9154 bp intragenic duplication in FANCB, covering the first coding exon 3 and the flanking regions. The duplicated allele gives rise to an aberrant transcript containing exon 3 duplication, predicted to introduce a stop codon in FANCB protein (p.A319*). PMID: 29193904
  2. Four single nucleotide polymorphisms were identified, three of which were located in untranslated regions of Fanconi anemia group B protein (FANCB) and predicted to be associated with normal function. PMID: 29491055
  3. Loss-of-function FANCB mutations result in a recognizable, multiple malformation phenotype in hemizygous males for which we propose clinical criteria to aid diagnosis. PMID: 21910217
  4. Inactivation of FancB may play a role in the pathogenesis of sporadic HNSCC. PMID: 20332657
  5. Elevated serum FA-2 was associated with bony metastases from breast cancer. PMID: 20465790
  6. the protein defective in individuals with Fanconi anemia belonging to complementation group B is an essential component of the nuclear protein 'core complex' responsible for monoubiquitination of FANCD2 PMID: 15502827
  7. summary of recent advances in the Fanconi anemia-BRCA network with emphasis on the new discovery of FAAP95 as the true FANCB gene [review] PMID: 15611632
  8. Mutations in FANCB are a cause of X linked VACTERL-H syndrome. PMID: 16679491
  9. Mus81 and FANCB have different roles in repair of DNA damage during replication in human cells PMID: 17903171
  10. Our results rule out a major contribution of FANCB to hereditary breast cancer. PMID: 18302019

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Involvement in disease
Fanconi anemia complementation group B (FANCB)
Subcellular Location
Nucleus.
Database Links

HGNC: 3583

OMIM: 300514

KEGG: hsa:2187

STRING: 9606.ENSP00000326819

UniGene: Hs.554740

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