Recombinant Human Fanconi anemia group B protein (FANCB), partial

Code CSB-YP818751HU
MSDS
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Source Yeast
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Code CSB-EP818751HU
MSDS
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Source E.coli
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Code CSB-EP818751HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP818751HU
MSDS
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Source Baculovirus
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Code CSB-MP818751HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FANCB
Uniprot No.
Alternative Names
FA2; FAAP90; FAAP95; FAB; FACB; Fancb; FANCB_HUMAN; Fanconi anemia associated polypeptide of 95 kDa ; Fanconi anemia group B protein; Fanconi anemia; complementation group B; Fanconi anemia-associated polypeptide of 95 kDa; Protein FACB
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
DNA repair protein required for FANCD2 ubiquitination.
Gene References into Functions
  1. We identified a 9154 bp intragenic duplication in FANCB, covering the first coding exon 3 and the flanking regions. The duplicated allele gives rise to an aberrant transcript containing exon 3 duplication, predicted to introduce a stop codon in FANCB protein (p.A319*). PMID: 29193904
  2. Four single nucleotide polymorphisms were identified, three of which were located in untranslated regions of Fanconi anemia group B protein (FANCB) and predicted to be associated with normal function. PMID: 29491055
  3. Loss-of-function FANCB mutations result in a recognizable, multiple malformation phenotype in hemizygous males for which we propose clinical criteria to aid diagnosis. PMID: 21910217
  4. Inactivation of FancB may play a role in the pathogenesis of sporadic HNSCC. PMID: 20332657
  5. Elevated serum FA-2 was associated with bony metastases from breast cancer. PMID: 20465790
  6. the protein defective in individuals with Fanconi anemia belonging to complementation group B is an essential component of the nuclear protein 'core complex' responsible for monoubiquitination of FANCD2 PMID: 15502827
  7. summary of recent advances in the Fanconi anemia-BRCA network with emphasis on the new discovery of FAAP95 as the true FANCB gene [review] PMID: 15611632
  8. Mutations in FANCB are a cause of X linked VACTERL-H syndrome. PMID: 16679491
  9. Mus81 and FANCB have different roles in repair of DNA damage during replication in human cells PMID: 17903171
  10. Our results rule out a major contribution of FANCB to hereditary breast cancer. PMID: 18302019

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Involvement in disease
Fanconi anemia complementation group B (FANCB)
Subcellular Location
Nucleus.
Database Links

HGNC: 3583

OMIM: 300514

KEGG: hsa:2187

STRING: 9606.ENSP00000326819

UniGene: Hs.554740

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