FBXL17 Antibody, HRP conjugated

Code CSB-PA866216LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FBXL17 Polyclonal antibody
Uniprot No.
Target Names
FBXL17
Alternative Names
DKFZP434C1715 antibody; F box and leucine rich repeat protein 17 antibody; F box only protein 13 antibody; F box/LRR repeat protein 17 antibody; F-box and leucine-rich repeat protein 17 antibody; F-box only protein 13 antibody; F-box/LRR-repeat protein 17 antibody; FBL17 antibody; FBX13 antibody; Fbxl17 antibody; FBXO13 antibody; FXL17_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human F-box/LRR-repeat protein 17 protein (1-303AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells. The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1. The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction. The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1.
Gene References into Functions
  1. In summary, these findings reveal Fbxl17 as a novel regulator of the Hedgehog signaling pathway and highlight the perturbation of the Fbxl17-Sufu axis in the pathogenesis of medulloblastoma. PMID: 27234298
  2. Identify a role for SCF(FBXL17) in controlling the threshold for NRF2-dependent gene activation via BACH1 repressor turnover. PMID: 24035498
  3. F-box protein 17 (FBXL17) can serve as a therapeutic target and surrogate marker for breast cancer therapy. PMID: 18820369
Subcellular Location
Cytoplasm. Nucleus.
Database Links

HGNC: 13615

OMIM: 609083

KEGG: hsa:64839

STRING: 9606.ENSP00000437464

UniGene: Hs.657225

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