FBXL17 Antibody

Datasheet

Code	CSB-PA866216LA01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FBXL17 Polyclonal antibody

Uniprot No.

Q9UF56

Target Names

FBXL17

Alternative Names

DKFZP434C1715 antibody; F box and leucine rich repeat protein 17 antibody; F box only protein 13 antibody; F box/LRR repeat protein 17 antibody; F-box and leucine-rich repeat protein 17 antibody; F-box only protein 13 antibody; F-box/LRR-repeat protein 17 antibody; FBL17 antibody; FBX13 antibody; Fbxl17 antibody; FBXO13 antibody; FXL17_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human F-box/LRR-repeat protein 17 protein (1-303AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The FBXL17 Antibody (Product code: CSB-PA866216LA01HU) is Non-conjugated. For FBXL17 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA866216LB01HU	FBXL17 Antibody, HRP conjugated	ELISA
FITC	CSB-PA866216LC01HU	FBXL17 Antibody, FITC conjugated
Biotin	CSB-PA866216LD01HU	FBXL17 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells. The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1. The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction. The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1.

Gene References into Functions

In summary, these findings reveal Fbxl17 as a novel regulator of the Hedgehog signaling pathway and highlight the perturbation of the Fbxl17-Sufu axis in the pathogenesis of medulloblastoma. PMID: 27234298
Identify a role for SCF(FBXL17) in controlling the threshold for NRF2-dependent gene activation via BACH1 repressor turnover. PMID: 24035498
F-box protein 17 (FBXL17) can serve as a therapeutic target and surrogate marker for breast cancer therapy. PMID: 18820369

Subcellular Location

Cytoplasm. Nucleus.

Database Links

HGNC: 13615

OMIM: 609083

KEGG: hsa:64839

STRING: 9606.ENSP00000437464

UniGene: Hs.657225

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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