FEV Antibody, HRP conjugated

Code CSB-PA858717LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FEV Polyclonal antibody
Uniprot No.
Target Names
FEV
Alternative Names
ETS-domain transcription factor antibody; FEV (ETS oncogene family) antibody; FEV antibody; FEV ETS transcription factor antibody; FEV_HUMAN antibody; Fifth Ewing sarcoma variant antibody; Fifth Ewing variant protein antibody; HSRNAFEV antibody; mPet1 antibody; PC12 ETS domain-containing transcription factor 1 antibody; PC12 ETS factor 1 antibody; Pet-1 antibody; Protein FEV antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein FEV protein (1-97AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
Gene References into Functions
  1. This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4, and FEV with aggressive behavior in Chinese adolescents. PMID: 28846959
  2. identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin PMID: 27807368
  3. Genetic variation in FEV1 was associated with serum 25-Hydroxyvitamin D status. PMID: 26122139
  4. novel evidence for the role of Pet-1 in human amygdala threat processing extends literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation PMID: 24100022
  5. Fev-ERK signaling is essential for hemogenic endothelium-based hematopoietic stem cell development. PMID: 23591790
  6. our data argue against an exclusive role of FEV in the adult human brain serotonergic system and genetic analyses did not suggest that FEV variation adds to the genetic liability towards affective disorders PMID: 20480378
  7. FEV identifies serotonin-producing cells in normal and neoplastic small intestine. PMID: 20048018
  8. Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population. PMID: 19707175
  9. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. PMID: 12761502
  10. We showed that fev is exclusively expressed in the midline part of the human brainstem containing raphe nuclei, which also specifically expressed 5-HT transporter (sert) and tryptophan hydroxylase (tph), two markers of the 5-HT neurotransmitter system. PMID: 15003288
  11. Analysis of transgene expression in Pet-1 null mice indicates that Pet-1 is required to maintain the activity of the Pet-1 enhancer region in a subset of serotonin (5-HT) neurons. PMID: 15758173
  12. Variation in FEV gene observed exclusively in a subset of African American sudden infant death syndrome cases may help explain the observed abnormalities of this system in some SIDS cases and the ethnic disparity. PMID: 17597646

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Involvement in disease
Sudden infant death syndrome (SIDS)
Subcellular Location
Nucleus.
Protein Families
ETS family
Tissue Specificity
In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.
Database Links

HGNC: 18562

OMIM: 272120

KEGG: hsa:54738

STRING: 9606.ENSP00000295727

UniGene: Hs.234759

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