FGGY Antibody,HRP conjugated

Code CSB-PA853393LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FGGY Polyclonal antibody
Uniprot No.
Target Names
FGGY
Alternative Names
FGGYFGGY carbohydrate kinase domain-containing protein antibody; EC 2.7.1.- antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human FGGY carbohydrate kinase domain-containing protein (1-244AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Antigen Affinity purified & Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency.
Gene References into Functions
  1. S. cerevisiae Ydr109c and human FGGY could act as metabolite repair enzymes, serving to re-phosphorylate free d-ribulose generated by promiscuous phosphatases from d-ribulose 5-phosphate. In human cells, FGGY can additionally participate in ribitol metabolism. PMID: 27909055
  2. Single-nucleotide polymorphism in FGGY is not associated with amyotrophic lateral sclerosis in a large Chinese cohort. PMID: 24439956
  3. The result of this study suggested that FLJI0986 that do not modulate the risk for SALS in the German population. PMID: 19464757
  4. This study indicated that mutations in fggy genes are unlikely to be a common cause of ALS in the French and French Canadian populations. PMID: 20001489
  5. Results suggest that common genetic variation in FGGY is not associated with susceptibility to sporadic ALS in genetically homogeneous populations from northern Europe. PMID: 19922138
  6. Variants of FLJ10986 may confer susceptibility to sporadic ALS (amyotrophic lateral sclerosis). PMID: 17671248

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Involvement in disease
Amyotrophic lateral sclerosis (ALS)
Protein Families
FGGY kinase family
Tissue Specificity
Expressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level).
Database Links

HGNC: 25610

OMIM: 105400

KEGG: hsa:55277

STRING: 9606.ENSP00000360262

UniGene: Hs.444301

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