Recombinant Human FGGY carbohydrate kinase domain-containing protein (FGGY)

Code CSB-YP853393HU
MSDS
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Source Yeast
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Code CSB-EP853393HU
MSDS
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Source E.coli
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Code CSB-EP853393HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP853393HU
MSDS
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Source Baculovirus
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Code CSB-MP853393HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FGGY
Uniprot No.
Alternative Names
FGGYFGGY carbohydrate kinase domain-containing protein; EC 2.7.1.-
Species
Homo sapiens (Human)
Expression Region
1-551
Target Protein Sequence
MSGGEQKPER YYVGVDVGTG SVRAALVDQS GVLLAFADQP IKNWEPQFNH HEQSSEDIWA ACCVVTKKVV QGIDLNQIRG LGFDATCSLV VLDKQFHPLP VNQEGDSHRN VIMWLDHRAV SQVNRINETK HSVLQYVGGV MSVEMQAPKL LWLKENLREI CWDKAGHFFD LPDFLSWKAT GVTARSLCSL VCKWTYSAEK GWDDSFWKMI GLEDFVADNY SKIGNQVLPP GASLGNGLTP EAARDLGLLP GIAVAASLID AHAGGLGVIG ADVRGHGLIC EGQPVTSRLA VICGTSSCHM GISKDPIFVP GVWGPYFSAM VPGFWLNEGG QSVTGKLIDH MVQGHAAFPE LQVKATARCQ SIYAYLNSHL DLIKKAQPVG FLTVDLHVWP DFHGNRSPLA DLTLKGMVTG LKLSQDLDDL AILYLATVQA IALGTRFIIE AMEAAGHSIS TLFLCGGLSK NPLFVQMHAD ITGMPVVLSQ EVESVLVGAA VLGACASGDF ASVQEAMAKM SKVGKVVFPR LQDKKYYDKK YQVFLKLVEH QKEYLAIMND D
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency.
Gene References into Functions
  1. S. cerevisiae Ydr109c and human FGGY could act as metabolite repair enzymes, serving to re-phosphorylate free d-ribulose generated by promiscuous phosphatases from d-ribulose 5-phosphate. In human cells, FGGY can additionally participate in ribitol metabolism. PMID: 27909055
  2. Single-nucleotide polymorphism in FGGY is not associated with amyotrophic lateral sclerosis in a large Chinese cohort. PMID: 24439956
  3. The result of this study suggested that FLJI0986 that do not modulate the risk for SALS in the German population. PMID: 19464757
  4. This study indicated that mutations in fggy genes are unlikely to be a common cause of ALS in the French and French Canadian populations. PMID: 20001489
  5. Results suggest that common genetic variation in FGGY is not associated with susceptibility to sporadic ALS in genetically homogeneous populations from northern Europe. PMID: 19922138
  6. Variants of FLJ10986 may confer susceptibility to sporadic ALS (amyotrophic lateral sclerosis). PMID: 17671248

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Involvement in disease
Amyotrophic lateral sclerosis (ALS)
Protein Families
FGGY kinase family
Tissue Specificity
Expressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level).
Database Links

HGNC: 25610

OMIM: 105400

KEGG: hsa:55277

STRING: 9606.ENSP00000360262

UniGene: Hs.444301

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