FHL2 Antibody

1. FHL2 is an important prognostic factor in cervical cancer (CC) and that it plays a crucial oncoprotein role by promoting cell proliferation and inhibiting apoptosis in CC. PMID: 29800735
2. FHL2 and iASPP interacted with each other and co-localized in both nucleus and cytoplasm. Either FHL2 or iASPP silenced could reduce cell proliferation, induce cell cycle arrest at G0/G1 phase, and increase cell apoptosis. PMID: 28402264
3. FHL2 phosphorylation by FAK is a critical, mechanically dependent step in signaling from soft matrices to the nucleus to inhibit cell proliferation by increasing p21 expression. PMID: 27742790
4. FHL2 facilitates ovarian granulosa cell tumor progression via controlling AKT1 transcription. PMID: 27415427
5. we determined the molecular mechanism responsible for IER3 degradation, involving a ternary complex of IER3, MDM2 and FHL2, which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein PMID: 26973248
6. FHL2 interacts with ADAM-17 in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17/FHL2 complex in the development of colorectal cancer. PMID: 28349819
7. FHL2 overexpression could enhance the differentiation and mineralization of human dental pulp cells PMID: 25662359
8. findings show that mAbp1 and FHL2 are novel binding partners that differentially regulate Rho GTPase signaling and MTLn3 breast cancer cell invasion PMID: 27129278
9. These results identify FHL2 as a novel gene associated with asthma severity in human. PMID: 26222912
10. FHL2 might interact with Runx2 to mediate mesenchymal cell differentiation at the early stages of tooth development and human dental pulp cell differentiation. PMID: 26759258
11. FHL2 overexpression could contribute to the growth, proliferation, invasiveness, and metastasis of human tongue squamous cell carcinoma. PMID: 26759260
12. KLF8-induced FHL2 activation is a novel and critical signaling mechanism underlying human colorectal cancer invasion and metastasis. PMID: 26320172
13. Studies indicate that the LIM-only protein FHL2 interactome is functionally involved in the cardiovascular system. PMID: 26548523
14. we conclude that FHL2 has both structural and functional protein-protein interactions with b-catenin in the podocyte nucleus and that FHL2 protein inhibition can mitigate Wnt/b-catenin-induced podocytopathy. PMID: 25855776
15. Describe the molecular network governing FHL2 expression, and FHL2-linked cancers and the underlying molecular machinery. Review. PMID: 26211626
16. Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in hereditary nonpolyposis colorectal cancer-associated colorectal cancer. PMID: 25554651
17. results provide evidence for the importance of the focal adhesion protein FHL2 in pancreatic cancer cell survival, proliferation and radiosensitivity PMID: 25917075
18. FHL2 is down-regulated in HCM; both FHL2 wild type and variants partially protected phenylephrine- or endothelin-1-induced hypertrophy in cardiac myocytes PMID: 25358972
19. FHL2 downregulation has a role in the pathogenesis of myeloid malignancies. PMID: 25179730
20. HPV16 E6 oncoprotein interacted and impaired the subcellular distribution of FHL2. PMID: 25540819
21. tumoural TGF-beta1 secretion seems to induce nuclear translocation of co-factor FHL2 mediating progressive keratin expression in pilomatricoma. PMID: 25477051
22. Enhanced FHL2 and TGF-beta1 expression is correlated with poor survival in human malignant melanoma PMID: 25596251
23. FHL2 is a transcriptional coactivator of LXRs and may be an important determinant of cholesterol metabolism in SMCs PMID: 25332231
24. High FHL2 expression is associated with colon cancer. PMID: 24008552
25. Data suggest Fhl1 (four-and-a-half LIM domains protein 1) and FHL2 (four-and-a-half LIM domains protein 2) bind to and regulate activity of Prkd1 (protein kinase D 1) in cardiac/ventricular myocytes; knockdown of FHL2 down-regulates Prkd1 activation. PMID: 24219103
26. The calpain-cleaved filamin fragment and FHL2 are present in the nucleus only in CRPC. PMID: 23801747
27. higher FHL2 expression in malignant epithelial cells correlates with progressive disease in patients with colorectal cancer, suggesting that FHL2 is a prognostic indicator for the development of metachronous metastases and for overall survival PMID: 23756870
28. FHL2 acts as an oncogene in osteosarcoma cells and contributes to tumorigenesis through Wnt signaling PMID: 23383046
29. PCBP2 is an RNA-binding protein that modulates glioma growth by regulating FHL3 PMID: 23585479
30. The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis. PMID: 22796152
31. Deletion of FHL2 protein by FHL2 small interfering RNA impaired VEGF production under hypoxia conditions, and also suppressed endothelial progenitor cell angiogenic functions. PMID: 23413425
32. FHL2 increases the stability of the TGF-beta pathway positive regulator Arkadia by inhibiting its ubiquitination and cooperates with Arkadia to activate TGF-beta signaling. PMID: 23212909
33. Overexpression of Id3 markedly promoted the proliferation and invasive capacity of MCF-7 cells; however, these effects were significantly suppressed by the overexpression of FHL2. PMID: 22882857
34. FHL2 modulates calcineurin-dependent activation of NFAT target genes. PMID: 22851699
35. On influenza A virus infection FHL2 translocates into the nucleus, potentiating the IRF-3-dependent transcription of the IFNbeta gene. PMID: 22417706
36. FHL2 directly interacts with HIF-1alpha to repress transcriptional activity. PMID: 22219185
37. association of FHL2 with Nur77 plays a pivotal role in vascular disease. PMID: 22049082
38. Overexpression of FHL2 in peritumoural myofibroblasts correlated to lymphatic metastasis in sporadic colon cancer but not in hereditary non-polyposis colorectal cancer. PMID: 21826055
39. Our data suggest a role of FHL2 in odontoblast differentiation and dentin formation both in normal and in carious teeth PMID: 21308406
40. In human colorectal carcinoma but not in low-grade dysplasia, we detected up-regulation and enhanced nuclear localization of FHL2, indicating the activation of FHL2 during the development of malignancy PMID: 20442768
41. our results indicate FHL2 could exert anti-apoptotic effect independent of tumor growth suppression PMID: 21377781
42. cooperative regulation of estrogen signaling by FHL2 and Smad4 in breast cancer cells, and might provide a new regulation mechanism underlying breast cancer development and progression PMID: 20734429
43. In the absence of transgenic FHL2, CCL19-induced bone marrow-derived dendritic cell migratory speed, persistence, and directionality were markedly increased in vitro and in vivo. PMID: 20592280
44. Sp1 up-regulates FHL2 expression in gastrointestinal cancers through transcription regulation. PMID: 20607723
45. FHL2 is a potent epithelial-mesenchymal transition (EMT) inducer and might be an important mediator for invasion and/or metastasis of colon cancer. PMID: 20460358
46. Aryl hydrocarbon receptor (AhR) modulation of androgen receptor activity is differentially altered by the level of FHL2 and AhR present in the cell. PMID: 19815066
47. Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2). PMID: 11821401
48. TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation. PMID: 12067710
49. evidence of a functional interaction between the promyelocytic leukemia zinc finger protein (PLZF) and DRAL/FHL2 PMID: 12145280
50. FHL2 might enforce beta-catenin transactivation activity in cancer cells PMID: 12466281

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HGNC: 3703

OMIM: 602633

KEGG: hsa:2274

STRING: 9606.ENSP00000322909

UniGene: Hs.443687