FHL3 Antibody

Code CSB-PA008665GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
FHL3
Alternative Names
FHL 3 antibody; FHL-3 antibody; Fhl3 antibody; FHL3_HUMAN antibody; Four and a half LIM domains 3 antibody; Four and a half LIM domains protein 3 antibody; Skeletal muscle LIM protein 2 antibody; Skeletal muscle LIM-protein 2 antibody; SLIM-2 antibody; SLIM2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human FHL3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.
Gene References into Functions
  1. the present study established a link between Ang and FHL3 proteins and identifies a new pathway for regulating astrocytoma progression. PMID: 25659096
  2. These findings suggest that functional interactions between FHL3 and MT-1X may provide some clues to the mechanisms of FHL3-regulated cell proliferation. PMID: 24690879
  3. PCBP2 could bind to FHL3 mRNA 3'UTR-A and inhibited the expression of FHL3 in T98G glioms cells PMID: 24998228
  4. FHL3 enhances Tax1-mediated activation of the Human T-cell leukemia virus type 1 long terminal repeat (LTR) without affecting basal activity and regulates NF-kappaB activation by Tax1 in a cell-specific manner. PMID: 23616667
  5. findings suggest that the interaction between Ang and FHL3 may provide some clues to the mechanisms of Ang-regulated cell growth and apoptosis PMID: 22633874
  6. FHL3 suppressed anchorage-dependent and -independent growth of human breast cancer cells. PMID: 22362714
  7. FHL3 does not bind to HIF-1alpha or p300, indicating that it regulates transactivation by a novel molecular mechanism. PMID: 22219185
  8. the second zinc finger motif in LIM4 was responsible for the auto-activation of FHL3. PMID: 20586194
  9. Data show that FHL3 (human four-and-a-half LIM-only protein 3) interacts with human phosphatase CDC25B in the cell nucleus. PMID: 12681290
  10. MZF-1 and FHL3 formed a complex of high molecular mass with some additional proteins in the nucleus. Transcriptional repression of FcepsilonRI by MZF-1 required FHL3. PMID: 15453830
  11. FHL3 association with MyoD may contribute to the regulation of MyoD-dependent transcription of muscle genes and thereby myogenesis PMID: 17389685

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Subcellular Location
Nucleus. Cytoplasm.
Tissue Specificity
Expressed only in skeletal muscle.
Database Links

HGNC: 3704

OMIM: 602790

KEGG: hsa:2275

STRING: 9606.ENSP00000362107

UniGene: Hs.57687

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