FHOD1 Antibody

Datasheet
Code CSB-PA896540LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q9Y613
Image
  • IHC image of CSB-PA896540LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human FH1/FH2 domain-containing protein 1 protein (338-437AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Relevance Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1), FHOD1, FHOS FHOS1
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names FHOD1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.
Subcellular Location Cytoplasm, Cytoplasm, cytoskeleton, Cell projection, bleb
Protein Families Formin homology family
Tissue Specificity Ubiquitous. Highly expressed in spleen.
Database Links

HGNC: 17905

OMIM: 606881

KEGG: hsa:29109

STRING: 9606.ENSP00000258201

UniGene: Hs.95231

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