FLRT3 Antibody, Biotin conjugated

Code CSB-PA882162LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FLRT3 Polyclonal antibody
Uniprot No.
Target Names
FLRT3
Alternative Names
fibronectin leucine rich transmembrane protein 3 antibody; Fibronectin-like domain-containing leucine-rich transmembrane protein 3 antibody; FLRT 3 antibody; FLRT3 antibody; FLRT3_HUMAN antibody; KIAA1469 antibody; Leucine-rich repeat transmembrane protein FLRT3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Leucine-rich repeat transmembrane protein FLRT3 protein (209-264AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina. Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members. Promotes neurite outgrowth (in vitro). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development.
Gene References into Functions
  1. Low FLRT3 expression is associated with lung graft dysfunction. PMID: 27421969
Involvement in disease
Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)
Subcellular Location
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cell junction, focal adhesion. Secreted. Cell projection, axon. Cell projection, growth cone membrane.
Tissue Specificity
Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.
Database Links

HGNC: 3762

OMIM: 604808

KEGG: hsa:23767

STRING: 9606.ENSP00000339912

UniGene: Hs.41296

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