FNBP1L Antibody

Code CSB-PA008763GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
FNBP1L
Alternative Names
C1orf39 antibody; FBP1L_HUMAN antibody; FNBP 1L antibody; fnbp1l antibody; Formin binding protein 1 like antibody; Formin-binding protein 1-like antibody; TOCA 1 antibody; Toca-1 antibody; TOCA1 antibody; Transducer of Cdc42 dependent actin assembly 1 antibody; Transducer of Cdc42 dependent actin assembly protein 1 antibody; Transducer of Cdc42-dependent actin assembly protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human FNBP1L
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
Gene References into Functions
  1. This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery. PMID: 27129201
  2. Loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease. PMID: 25547174
  3. GWAS results show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts; FNBP1L was also significantly associated with childhood intelligence PMID: 23358156
  4. findings suggest that Toca-1 functions at an early step in the dissemination of metastatic breast tumor cells; taken together, results identify Toca-1 as a proinvasive protein in breast adenocarcinoma PMID: 22824798
  5. Toca-1 knockdown cells also display a significant defect in EGF-induced motility and invasiveness. PMID: 21062739
  6. Cdc42 may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP complex. PMID: 20730103
  7. Toca-1 promotes actin nucleation by activating the N-WASP-WIP/CR16 complex, the predominant form of N-WASP in cells. PMID: 15260990
  8. a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP PMID: 16885158
  9. We show that actin tail initiation by S. flexneri requires Toca-1 for the conversion of N-WASP from a closed inactive conformation to an open active one. PMID: 18191793
  10. the Toca-1-N-WASP complex can link filopodial formation to endocytosis PMID: 19213734
  11. FNBP1L appears dispensable for other forms of autophagy induced by serum starvation or rapamycin PMID: 19342671
  12. Human FNBP1L binds the autophagy protein Atg3 and is required for autophagy of Salmonella Typhimurium in epithelial cells PMID: 19342671

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Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
FNBP1 family
Database Links

HGNC: 20851

OMIM: 608848

KEGG: hsa:54874

STRING: 9606.ENSP00000271234

UniGene: Hs.134060

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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