FOXH1 Antibody, HRP conjugated

Code CSB-PA008817LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FOXH1 Polyclonal antibody
Uniprot No.
Target Names
FOXH1
Alternative Names
FAST 1 antibody; Fast 2 antibody; Fast-1 antibody; Fast-2 antibody; FAST1 antibody; Fast2 antibody; Forkhead activin signal transducer 1 antibody; Forkhead activin signal transducer 2 antibody; Forkhead box H1 antibody; Forkhead box protein H1 antibody; FOX H1 antibody; FOXH 1 antibody; FOXH1 antibody; FOXH1_HUMAN antibody; hFAST 1 antibody; hFAST-1 antibody; hFAST1 antibody; Human homolog of Xenopus forkhead activin signal transducer 1 antibody; TGF beta/Activin signal transducer FAST1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Forkhead box protein H1 protein (153-269AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
Gene References into Functions
  1. These results indicate that Smad4 acts as a tumor suppressor by activating FOXH1, and then suppressing the expression of estrogen receptor, in addition to tumor migration and invasion. PMID: 25482028
  2. HEB and E2A-bind the SCA motif at regions overlapping SMAD2/3 and FOXH1 PMID: 21828274
  3. Four genetic variants are found in FOXH1 that are associated with ventricular septal defects in Chinese patients. PMID: 19525021
  4. Results suggest that PKA can negatively regulate ERalpha, at least in part, through FoxH1. PMID: 19711044
  5. This work suggests that FAST-1 may participate in the vascular smooth muscle response to injury and may represent a potential molecular target for modulating the progression of cardiac allograft vasculopathy. PMID: 15737749
  6. Smad-binding peptide aptamer FOXH1 can be developed to selectively inhibit TGF-beta-induced gene expression. PMID: 15750622
  7. These results demonstrate for a functional role for TGF-beta ligands in regulation of mammalian Mixl1, identify FoxH1 as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis. PMID: 15982639
  8. FoxH1 has a role in androgen receptor-mediated transactivation PMID: 16120611
  9. Reduced NODAL signaling via mutation of several pathway members including FOXH1 is linked to heart defects and holoprosencephaly. PMID: 18538293

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Subcellular Location
Nucleus.
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 3814

OMIM: 603621

KEGG: hsa:8928

STRING: 9606.ENSP00000366534

UniGene: Hs.708365

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