FOXN1 Antibody

Datasheet

Code	CSB-PA008829LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Raji whole cell lysate, Mouse lung tissue, Mouse stomach tissue All lanes: FOXN1 antibody at 2.7µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 69 kDa Observed band size: 69 kDa Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA008829LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA008829LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FOXN1 Polyclonal antibody

Uniprot No.

O15353

Target Names

FOXN1

Alternative Names

FKHL20 antibody; Forkhead box N1 antibody; Forkhead box protein N1 antibody; FOXN 1 antibody; FOXN1 antibody; FOXN1_HUMAN antibody; RONU antibody; Rowett nude antibody; Transcription factor winged-helix nude antibody; WHN antibody; Winged helix nude antibody; Winged-helix transcription factor nude antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Forkhead box protein N1 protein (1-160AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The FOXN1 Antibody (Product code: CSB-PA008829LA01HU) is Non-conjugated. For FOXN1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA008829LB01HU	FOXN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008829LC01HU	FOXN1 Antibody, FITC conjugated
Biotin	CSB-PA008829LD01HU	FOXN1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The FOXN1 antibody (CSB-PA008829LA01HU) is a polyclonal antibody raised in rabbits immunized with a peptide mapping within amino acids 1-160 of the recombinant human FOXN1. It exists as an unconjugated IgG. Its purity is greater than 95% using protein G purified. And it is reactive with human and mouse FOXN1 protein, a transcription factor involved in the formation of the thymus. Dysfunction of FOXN1 leads to a severe T cell developmental block due to thymic agenesis and is also related to alopecia and nail dystrophy. This FOXN1 antibody has been validated for use in ELISA, WB, and IHC applications.

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Target Background

Function

Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C. Plays a crucial role in the early prenatal stages of T-cell ontogeny.

Gene References into Functions

FOXN1 founder Italian mutation identified in an indian newborn with severe combined immunodeficiency. PMID: 28636882
Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism spectrum disorders. PMID: 26352270
Identification of a unique mutation in FOXN1 that led to severe combined immunodeficiency in a female infant is reported. PMID: 25173801
These results show that miR-18b and miR-518b are upstream controllers of FOXN1-directed epithelial lineage development. PMID: 24383669
The retinoid-related orphan receptor RORalpha promotes keratinocyte differentiation via FOXN1. PMID: 23922987
This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation. PMID: 22721479
results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation PMID: 21507891
role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review] PMID: 20429426
study uncovered a positive regulatory loop between FGFR3 and FOXN1 that underlies a benign versus malignant skin tumor phenotype PMID: 19729838
Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency associated with alopecia PMID: 15180707
These results establish a role for FOXN1 in initiation of terminal differentiation and implicate Akt in subsequent events. PMID: 15316080
Mechanisms and signaling pathways by which Foxn1 modulates keratinocyte differentiation in hair follicle and nail apparatus. Molecular and functional consequences of loss of function of Foxn1 protein in skin. Review. PMID: 16232301
Foxn1 is a sensitive and specific marker for thymoma and thymic carcinoma. PMID: 17592270
Foxn1/FGF2 pathway involved in instructing melanocytes where to place pigment. PMID: 17803914

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Involvement in disease

T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND)

Subcellular Location

Nucleus.

Tissue Specificity

Expressed in thymus.

Database Links

HGNC: 12765

OMIM: 600838

KEGG: hsa:8456

STRING: 9606.ENSP00000226247

UniGene: Hs.58611

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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