FOXR2 Antibody

Code CSB-PA968818
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA968818(FOXR2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA968818(FOXR2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell, Primary antibody: CSB-PA968818(FOXR2 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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Product Details

Uniprot No.
Target Names
FOXR2
Alternative Names
Forkhead box protein N6 antibody; Forkhead box protein R2 antibody; FOXN6 antibody; Foxr2 antibody; FOXR2_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Full length fusion protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. FOXR2 might be considered as a promising therapeutic target for non-small cell lung cancer treatment. PMID: 29634928
  2. FOXR2 was up-regulated and significantly associated with poor endometrial adenocarcinoma prognosis. FOXR2 is a target gene of miR-202. PMID: 28827892
  3. FOXR2 acts with MYC to promote cancer cell proliferation, which is a potential tumor-specific target for therapeutic intervention against MYC-driven cancers. PMID: 27346356
  4. our data suggested that FOXR2 significantly promoted proliferation, invasion, and EMT of CRC cells. All these findings provided evidence for the role of FOXR2 as an oncogene in CRC development. PMID: 28548041
  5. Knockdown of FOXR2 significantly down-regulated the protein expression levels of beta-catenin. PMID: 28068638
  6. FOXR2 is frequently upregulated in hepatocellular carcinoma specimens compared with neighboring non-cancerous tissues in both messenger RNA and protein. It promoted cell growth and colony formation, and it facilitated tumor xenograft growth. beta-catenin, Skp2, c-Myc, and Gli-1 are the potential downstream effectors of FOXR2. PMID: 26846213
  7. we observed that the highly expressed FOXR2 in breast and overexpression of FOXR2 was positively associated with the progression and poor prognosis in patients with breast cancer, which indicated that FOXR2 might serve as a valuable prognosis biomarker for breast cancer individuals. PMID: 26596836
  8. Human FOXN6 gene was identified within human genome sequence RP11-167P23 ( PMID: 15202009

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Subcellular Location
Nucleus.
Tissue Specificity
Expressed in breast cancer cell lines and primary cancer.
Database Links

HGNC: 30469

OMIM: 300949

KEGG: hsa:139628

STRING: 9606.ENSP00000427329

UniGene: Hs.364260

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