FRS3 Antibody

Code CSB-PA009005LA01HU
Size US$166
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  • Immunofluorescence staining of U251 cells with CSB-PA009005LA01HU at 1:466, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

  • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA009005LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA009005LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FRS3 Polyclonal antibody
Uniprot No.
Target Names
FRS3
Alternative Names
FRS3Fibroblast growth factor receptor substrate 3 antibody; FGFR substrate 3 antibody; FGFR-signaling adaptor SNT2 antibody; Suc1-associated neurotrophic factor target 2 antibody; SNT-2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Fibroblast growth factor receptor substrate 3 protein (101-400AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The FRS3 Antibody (Product code: CSB-PA009005LA01HU) is Non-conjugated. For FRS3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009005LB01HU FRS3 Antibody, HRP conjugated ELISA
FITC CSB-PA009005LC01HU FRS3 Antibody, FITC conjugated
Biotin CSB-PA009005LD01HU FRS3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
Gene References into Functions
  1. Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR family members and suggest a role for FRS2beta as a tumor suppressor. PMID: 20228838
  2. an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings PMID: 23279575
  3. FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors PMID: 11877385
  4. FRS2beta can compensate for the loss of FRS2alpha for activation of MAP kinase when expressed in fibroblasts PMID: 15094036
  5. SNT-2 negatively regulates ERK2 signaling activated via EGF stimulation through direct binding to ERK2 PMID: 15485655
  6. Novel mechanism of negative control of EGFR tyrosine kinase activity with SNT-2 by recruiting ERK2. PMID: 16702953

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Subcellular Location
Membrane; Lipid-anchor.
Database Links

HGNC: 16970

OMIM: 607744

KEGG: hsa:10817

STRING: 9606.ENSP00000259748

UniGene: Hs.194208

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