FRS3 Antibody

Code CSB-PA002585
Size US$100
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  • Western Blot analysis of COS7 cells using FRS3 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
FRS3
Alternative Names
FRS3Fibroblast growth factor receptor substrate 3 antibody; FGFR substrate 3 antibody; FGFR-signaling adaptor SNT2 antibody; Suc1-associated neurotrophic factor target 2 antibody; SNT-2 antibody
Raised in
Rabbit
Species Reactivity
Human,Monkey
Immunogen
Synthesized peptide derived from the Internal region of Human FRS3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
Gene References into Functions
  1. Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR family members and suggest a role for FRS2beta as a tumor suppressor. PMID: 20228838
  2. an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings PMID: 23279575
  3. FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors PMID: 11877385
  4. FRS2beta can compensate for the loss of FRS2alpha for activation of MAP kinase when expressed in fibroblasts PMID: 15094036
  5. SNT-2 negatively regulates ERK2 signaling activated via EGF stimulation through direct binding to ERK2 PMID: 15485655
  6. Novel mechanism of negative control of EGFR tyrosine kinase activity with SNT-2 by recruiting ERK2. PMID: 16702953

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Subcellular Location
Membrane; Lipid-anchor.
Database Links

HGNC: 16970

OMIM: 607744

KEGG: hsa:10817

STRING: 9606.ENSP00000259748

UniGene: Hs.194208

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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