G0S2 Antibody

Datasheet

Code	CSB-PA009114EA01HU
Size	US$166
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Image	IHC image of CSB-PA009114EA01HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) G0S2 Polyclonal antibody

Uniprot No.

P27469

Target Names

G0S2

Alternative Names

G0/G1 switch regulatory protein 2 antibody; G0/G1switch 2 antibody; G0s2 antibody; G0S2_HUMAN antibody; OTTHUMP00000034644 antibody; Putative lymphocyte G0/G1 switch protein 2 antibody; RP1 28O10.2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human G0/G1 switch protein 2 protein (1-103AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The G0S2 Antibody (Product code: CSB-PA009114EA01HU) is Non-conjugated. For G0S2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA009114EB01HU	G0S2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009114EC01HU	G0S2 Antibody, FITC conjugated
Biotin	CSB-PA009114ED01HU	G0S2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The product is a G0S2 polyclonal antibody produced in the rabbit immunized by the recombinant G0S2 protein. This antibody exists as an unconjugated IgG isoform. Its purity is greater than 95% purified by protein G. It shows reactivity with human and mouse G0S2 protein. And it has been rigorously quality tested in ELISA, WB, and IHC. Its target protein G0S2 plays an important role in adipogenesis and accumulation of triacylglycerol.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

Gene References into Functions

ER+ breast cancer cells with restored G0S2 expression had a relative increased sensitivity to tamoxifen PMID: 28910567
Palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPbeta-mediated G0S2 expression. PMID: 29209111
G0S2 functions as a master regulator of tissue-specific balance of TG storage vs. mobilization, partitioning of metabolic fuels between adipose and liver, and the whole-body adaptive energy response. PMID: 28645852
PML/RARalpha synergizes with C/EBPepsilon to reactivate the C/EBPepsilon target G0S2, thereby contributing to All-trans retinoic acid -mediated acute promyelocytic leukemia differentiation and potentially, clinical remission. PMID: 27605212
differences in G0S2 expression may explain depot-specific and obesity-associated differences in lipolysis on the molecular level PMID: 26707160
Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 product (G0S2) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL). PMID: 26318046
Results indicate that G0S2 acts as a prosurvival molecule in endothelial cells. PMID: 25588877
Data indicate that the peptide corresponding to residues Lys-20 to Ala-52 from G0S2 Inhibits ATGL in the nanomolar range. PMID: 25258314
reelin expression is altered by Abeta leading to impaired reelin signaling. PMID: 23951308
A new mechanism that controls proliferation in K562 cells, suggesting a possible tumor suppressor function for G0S2 in leukemia cells. PMID: 24183236
This linked G0S2 subcellular localization to G0S2 transcriptional repression. The potential mechanisms responsible for this G0S2 repression are examined. PMID: 23546556
Data indicate that downregulation of G0S2 in adipose tissue could represent one of the underlying causes leading to increased lipolysis in the insulin-resistant state. PMID: 22891293
Gene expression profiles showed that G0/G1 switch 2 was up-regulated in epidermolysis bullosa subtypes. PMID: 22716248
Reduced mRNA and protein content of Plin and G0S2 and borderline increased ATGL protein in sc adipose tissue from poorly controlled type 2 diabetic subjects. PMID: 22535977
findings are compatible with the notion that the ATGL-G0S2 complex is an important long-term regulator of lipolysis under physiological conditions such as fasting in humans PMID: 21613358
DNA methylation of G0S2 can be an important biomarker for squamous lung cancer. PMID: 19816938
mRNA expression of G0S2 was regulated mainly by DNA methylation in squamous lung cancer cell lines. PMID: 19878646
A novel putative target gene of PPARalpha, G0S2 (G0/G1 switch gene 2) was identified and characterized. PMID: 16086669
G0S2 is an all-trans-retinoic acid target gene PMID: 18636162
G0S2 encodes a mitochondrial protein that specifically interacts with Bcl-2 and promotes apoptosis by preventing the formation of protective Bcl-2/Bax heterodimers PMID: 19706769

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Subcellular Location

Mitochondrion.

Tissue Specificity

Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver.

Database Links

HGNC: 30229

OMIM: 614447

KEGG: hsa:50486

STRING: 9606.ENSP00000355996

UniGene: Hs.432132

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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