G0S2 Antibody

1. ER+ breast cancer cells with restored G0S2 expression had a relative increased sensitivity to tamoxifen PMID: 28910567
2. Palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPbeta-mediated G0S2 expression. PMID: 29209111
3. G0S2 functions as a master regulator of tissue-specific balance of TG storage vs. mobilization, partitioning of metabolic fuels between adipose and liver, and the whole-body adaptive energy response. PMID: 28645852
4. PML/RARalpha synergizes with C/EBPepsilon to reactivate the C/EBPepsilon target G0S2, thereby contributing to All-trans retinoic acid -mediated acute promyelocytic leukemia differentiation and potentially, clinical remission. PMID: 27605212
5. differences in G0S2 expression may explain depot-specific and obesity-associated differences in lipolysis on the molecular level PMID: 26707160
6. Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 product (G0S2) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL). PMID: 26318046
7. Results indicate that G0S2 acts as a prosurvival molecule in endothelial cells. PMID: 25588877
8. Data indicate that the peptide corresponding to residues Lys-20 to Ala-52 from G0S2 Inhibits ATGL in the nanomolar range. PMID: 25258314
9. reelin expression is altered by Abeta leading to impaired reelin signaling. PMID: 23951308
10. A new mechanism that controls proliferation in K562 cells, suggesting a possible tumor suppressor function for G0S2 in leukemia cells. PMID: 24183236
11. This linked G0S2 subcellular localization to G0S2 transcriptional repression. The potential mechanisms responsible for this G0S2 repression are examined. PMID: 23546556
12. Data indicate that downregulation of G0S2 in adipose tissue could represent one of the underlying causes leading to increased lipolysis in the insulin-resistant state. PMID: 22891293
13. Gene expression profiles showed that G0/G1 switch 2 was up-regulated in epidermolysis bullosa subtypes. PMID: 22716248
14. Reduced mRNA and protein content of Plin and G0S2 and borderline increased ATGL protein in sc adipose tissue from poorly controlled type 2 diabetic subjects. PMID: 22535977
15. findings are compatible with the notion that the ATGL-G0S2 complex is an important long-term regulator of lipolysis under physiological conditions such as fasting in humans PMID: 21613358
16. DNA methylation of G0S2 can be an important biomarker for squamous lung cancer. PMID: 19816938
17. mRNA expression of G0S2 was regulated mainly by DNA methylation in squamous lung cancer cell lines. PMID: 19878646
18. A novel putative target gene of PPARalpha, G0S2 (G0/G1 switch gene 2) was identified and characterized. PMID: 16086669
19. G0S2 is an all-trans-retinoic acid target gene PMID: 18636162
20. G0S2 encodes a mitochondrial protein that specifically interacts with Bcl-2 and promotes apoptosis by preventing the formation of protective Bcl-2/Bax heterodimers PMID: 19706769

Show More

Hide All

HGNC: 30229

OMIM: 614447

KEGG: hsa:50486

STRING: 9606.ENSP00000355996

UniGene: Hs.432132