GALR2 Antibody

Datasheet

Code	CSB-PA009224LA01HU
Size	US$166
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Image	Immunofluorescence staining of A549 cells with CSB-PA009224LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GALR2 Polyclonal antibody

Uniprot No.

O43603

Target Names

GALR2

Alternative Names

GALR2; GALNR2; Galanin receptor type 2; GAL2-R; GALR-2

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Galanin receptor type 2 protein (282-387AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The GALR2 Antibody (Product code: CSB-PA009224LA01HU) is Non-conjugated. For GALR2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA009224LB01HU	GALR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009224LC01HU	GALR2 Antibody, FITC conjugated
Biotin	CSB-PA009224LD01HU	GALR2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

Gene References into Functions

Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. PMID: 27685843
GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis PMID: 26572146
The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer PMID: 24568968
In HEp-2 cells, GALR2-mediated apoptosis was caspase-independent. PMID: 24168112
Activation of GalR2 leads to elevation of intracellular Ca(2+) due to Ca(2+) efflux from endoplasmic reticulum through IP3R sequentially opening BK alpha channels. PMID: 24602615
The expression of GALR2 mRNA is lost in head and neck squamous cell carcinoma as a consequence of DNA methylation.Silencing of the GALR2 gene by methylation may be a critical event in head and neck squamous cell carcinoma. PMID: 24122450
galanin receptor 2 promotes cell proliferation and survival, and promotes tumor growth, consistent with an oncogenic role for GALR2 in squamous cell carcinoma of the head and neck PMID: 21345369
Elevated expression of galanin receptors in childhood neuroblastic tumors PMID: 11867941
study indicates that a high level of GalR2 galanin receptor expression is able to inhibit cell proliferation and induce apoptosis in neuroblastoma cells PMID: 14592962
There was no effect of GALR2 on alcoholism risk. PMID: 17083333
point to GalR2 as a possible target for therapeuthic interventions in pheochromocytoma PMID: 18272487

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.

Database Links

HGNC: 4133

OMIM: 603691

KEGG: hsa:8811

STRING: 9606.ENSP00000329684

UniGene: Hs.666366

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

G protein coupled receptor signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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