GAS2 Antibody

Datasheet

Code	CSB-PA009265LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Jurkat whole cell lysate, Rat liver tissue All lanes: GAS2 antibody at 3.3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 35, 16 kDa Observed band size: 35 kDa IHC image of CSB-PA009265LA01HU diluted at 1:1000 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GAS2 Polyclonal antibody

Uniprot No.

O43903

Target Names

GAS2

Alternative Names

GAS 2 antibody; GAS-2 antibody; Gas2 antibody; GAS2_HUMAN antibody; Growth arrest specific 2 antibody; Growth arrest specific protein 2 antibody; Growth arrest-specific protein 2 antibody; MGC32610 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Growth arrest-specific protein 2 protein (1-141AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The GAS2 Antibody (Product code: CSB-PA009265LA01HU) is Non-conjugated. For GAS2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA009265LB01HU	GAS2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009265LC01HU	GAS2 Antibody, FITC conjugated
Biotin	CSB-PA009265LD01HU	GAS2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:1000-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.

Gene References into Functions

Taken together, our results demonstrated the deregulation of GAS2 in both AML and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells. PMID: 26358320
Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 signaling. PMID: 25925944
GAS2 is up-regulated in chronic myeloid leukemia cells. PMID: 24465953
Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia. PMID: 20679491
Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin PMID: 15817486

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Subcellular Location

Cytoplasm, cytoskeleton, stress fiber. Membrane; Peripheral membrane protein.

Protein Families

GAS2 family

Tissue Specificity

Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.

Database Links

HGNC: 4167

OMIM: 602835

KEGG: hsa:2620

STRING: 9606.ENSP00000278187

UniGene: Hs.711297

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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