GATAD2B Antibody, FITC conjugated

Code CSB-PA823905LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GATAD2B Polyclonal antibody
Uniprot No.
Target Names
GATAD2B
Alternative Names
FLJ37346 antibody; GATA zinc finger domain containing 2B antibody; GATA zinc finger domain containing protein 2B antibody; GATA zinc finger domain-containing protein 2B antibody; GATAD2B antibody; KIAA1150 antibody; MGC138257 antibody; MGC138285 antibody; mKIAA1150 antibody; p66/p68 antibody; P66B_HUMAN antibody; P66beta antibody; RGD1308533 antibody; transcription repressor p66 beta component of the MeCP1 complex antibody; Transcriptional repressor p66 beta antibody; Transcriptional repressor p66-beta antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcriptional repressor p66-beta protein (58-146AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.
Gene References into Functions
  1. GATAD2B interacts with C-MYC to enhance KRAS driven tumor growth. PMID: 30013058
  2. This data suggests that 1q21.3 microdeletion is a recurrent microdeletion syndrome with distinguishable phenotypes, and loss of function of GATAD2B is the major contributor of the characteristic facies and ID. PMID: 28211977
  3. findings suggest that GATAD2B serves as an important mediator of progesterone-progesterone receptor suppression of proinflammatory and contractile genes during pregnancy; decreased GATAD2B expression near term may contribute to the decline in progesterone receptor function, leading to labor PMID: 28576827
  4. This is the first report of GATAD2B in Chinese ID patients. Our findings will broaden the spectrum of GATAD2B mutations and facilitate genetic diagnosis and counseling. PMID: 28077840
  5. p66beta might be important for the regulation of LOX in the nucleus. PMID: 25118846
  6. Detailed clinical description showed that all four individuals with a GATAD2B aberration had a distinctive phenotype with childhood hypotonia, severe intellectual disability. PMID: 23644463
  7. identification as potent transcriptional repressors interacting with MBD2 and MBD3 PMID: 12183469

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Involvement in disease
Mental retardation, autosomal dominant 18 (MRD18)
Subcellular Location
Nucleus speckle.
Tissue Specificity
Widely expressed.
Database Links

HGNC: 30778

OMIM: 614998

KEGG: hsa:57459

STRING: 9606.ENSP00000357644

UniGene: Hs.4779

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