GBP5 Antibody, Biotin conjugated

Code CSB-PA847203LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GBP5 Polyclonal antibody
Uniprot No.
Target Names
GBP5
Alternative Names
GBP 5 antibody; GBP TA antigen antibody; GBP-5 antibody; GBP-TA antigen antibody; GBP5 antibody; GBP5_HUMAN antibody; GTP binding protein 5 antibody; GTP-binding protein 5 antibody; Guanine nucleotide binding protein 5 antibody; Guanine nucleotide-binding protein 5 antibody; Guanylate binding protein 5 antibody; Guanylate-binding protein 5 antibody; UNQ2427/PRO4987 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Guanylate-binding protein 5 protein (321-500AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP.
Gene References into Functions
  1. GBP5 and KLF2 may be useful as a diagnostic tool for active tuberculosis, also the two-gene set may serve as surrogate biomarkers for monitoring tuberculosis therapy. PMID: 28941629
  2. these results reveal that GBP5 inhibited influenza virus replication through the activation of IFN signaling and proinflammatory factors PMID: 28376501
  3. Previously reported tetrameric and dimeric species of hGBP-1 and hGBP-5 were unmasked as dimers and monomers, respectively, with their shapes depending on both the bound nucleotide and the ionic strength of the solution. PMID: 28580591
  4. Antiviral activity requires Golgi localization of GBP5, but not its GTPase activity. PMID: 26996307
  5. GZMA, GBP5 and CD64 genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases. PMID: 26025597
  6. The in vivo localization of GBP-5 at the Golgi apparatus is regulated by isoprenylation and dimerization. PMID: 21151871
  7. analysis of guanylate binding protein 5 and a tumor-specific truncated splice variant PMID: 20180847
  8. Eight of nine melanoma cell lines expressed GBP-5a/b and four of nine additionally low levels of GBP-5ta. PMID: 15175044
  9. 3 genes were upregulated in patients with chronic EBV infection: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5; they may be associated with the inflammatory reaction or with cell proliferation. PMID: 18260761
  10. GBP5 is constitutively localized in the Golgi apparatus of endothelial cells. PMID: 17266443

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Subcellular Location
Cytoplasm. Golgi apparatus membrane; Lipid-anchor.
Protein Families
TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
Tissue Specificity
Expressed in peripheral blood monocytes (at protein level).
Database Links

HGNC: 19895

OMIM: 611467

KEGG: hsa:115362

STRING: 9606.ENSP00000340396

UniGene: Hs.513726

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