GDF1 Antibody

Datasheet

Code	CSB-PA159987
Size	US$166
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Image	Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA159987(GDF1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Target Background

Product Details

Uniprot No.

P27539

Target Names

GDF1

Alternative Names

DORV antibody; DTGA3 antibody; Embryonic growth/differentiation factor 1 antibody; GDF 1 antibody; GDF-1 antibody; GDF1 antibody; GDF1_HUMAN antibody; Growth differentiation factor 1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human GDF1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May mediate cell differentiation events during embryonic development.

Gene References into Functions

Our results suggest that the GDF1 rs4808863 polymorphism contributes to an increased risk of fetal CHDs, especially the subtypes of AVSD, LVOTO and left-right laterality defects. PMID: 26656983
This implies that Gdf1 potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2. PMID: 24798330
indicate that the expression of growth/differentiation factor 1 (GDF1) is up-regulated in human dilated cardiomyopathy (DCM)hearts and murine hypertrophic hearts. PMID: 24275554
GDF1 may be associated with congenital heart defects risk, and these variations contribute at least in part to the development of some subtypes of conotruncal defects in the Chinese Han population. PMID: 23076529
Molecular genetic basis of a kindred with 5 siblings with right atrial isomerism involved mutations in GDF1. PMID: 20413652
Heterozygous loss-of-function mutations in the human GDF1 gene contribute to cardiac defects ranging from tetralogy of Fallot to transposition of the great arteries. PMID: 17924340
GDF1 expression is correlated with progression and aggressive behaviors in cervical cancer, suggesting a tumor-promoting role for GDF1 in the progression of this malignancy. PMID: 19359031

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Involvement in disease

Conotruncal heart malformations (CTHM); Transposition of the great arteries dextro-looped 3 (DTGA3); Tetralogy of Fallot (TOF); Right atrial isomerism (RAI)

Subcellular Location

Secreted.

Protein Families

TGF-beta family

Tissue Specificity

Expressed in the brain.

Database Links

HGNC: 4214

OMIM: 187500

KEGG: hsa:2657

STRING: 9606.ENSP00000247005

UniGene: Hs.412355

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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