GGPS1 Antibody

Code CSB-PA009393HA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA009393HA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA009393HA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GGPS1 Polyclonal antibody
Uniprot No.
Target Names
GGPS1
Alternative Names
(2E antibody; 6E)-farnesyl diphosphate synthase antibody; Dimethylallyltranstransferase antibody; Farnesyl diphosphate synthase antibody; Farnesyltranstransferase antibody; Geranylgeranyl diphosphate synthase 1 antibody; Geranylgeranyl diphosphate synthase antibody; Geranylgeranyl pyrophosphate synthase antibody; Geranylgeranyl pyrophosphate synthetase antibody; Geranyltranstransferase antibody; GGPP synthase antibody; GGPP synthetase antibody; GGPPS antibody; GGPPS_HUMAN antibody; GGPPS1 antibody; GGPPSase antibody; GGPS1 antibody; OTTHUMP00000036073 antibody; OTTHUMP00000216161 antibody; OTTHUMP00000216163 antibody; OTTHUMP00000216164 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Geranylgeranyl pyrophosphate synthase protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GGPS1 Antibody (Product code: CSB-PA009393HA01HU) is Non-conjugated. For GGPS1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009393HB01HU GGPS1 Antibody, HRP conjugated ELISA
FITC CSB-PA009393HC01HU GGPS1 Antibody, FITC conjugated
Biotin CSB-PA009393HD01HU GGPS1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Gene References into Functions
  1. results may support a model in which accumulation of susceptibility variants (including some in relevant genes, notably GGPS1) may lead to a possible genetic component of predisposition to atypical femoral fractures. PMID: 28467865
  2. GGPPS1 may play a critical role during the development of HCC from cirrhosis and is of clinical significance for predicting biological character of HCC. PMID: 24716791
  3. Egr-1 most likely does not induce the constitutive activation of Erk1/2 through its target gene GGPS1. PMID: 23478574
  4. the Egr-1/GGPPS/Erk1/2 pathway is responsible for insulin resistance during hyperinsulinism PMID: 21321112
  5. these results reveal a new EGR-1/GGPPS/MAPK signaling pathway that controls cigarette smoke-induced pulmonary inflammation. PMID: 21224049
  6. Study suggested that GGPS1 -8188A ins/del polymorphism may confer susceptibility to femoral neck BMD response to bisphosphonate therapy in Korean women. PMID: 20191015
  7. crystal structure; it reveals that three dimers join together to form a propeller-bladed hexameric molecule with a mass of approximately 200 kDa PMID: 16698791
  8. Farnesyltranstransferase mutations are associated with lonafarnib resistance PMID: 17536018
  9. results indicate that the active form of GGPS in the solution is an octamer rather than hexamer or dimer PMID: 17646172
  10. Evidence for a non-membrane bound isoform of geranylgeranyl diphosphate synthase 1 in rat. PMID: 8419360

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Subcellular Location
Cytoplasm.
Protein Families
FPP/GGPP synthase family
Tissue Specificity
Abundantly expressed in testis. Found in other tissues to a lower extent.
Database Links

HGNC: 4249

OMIM: 606982

KEGG: hsa:9453

STRING: 9606.ENSP00000282841

UniGene: Hs.730768

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