GGPS1 Antibody

1. results may support a model in which accumulation of susceptibility variants (including some in relevant genes, notably GGPS1) may lead to a possible genetic component of predisposition to atypical femoral fractures. PMID: 28467865
2. GGPPS1 may play a critical role during the development of HCC from cirrhosis and is of clinical significance for predicting biological character of HCC. PMID: 24716791
3. Egr-1 most likely does not induce the constitutive activation of Erk1/2 through its target gene GGPS1. PMID: 23478574
4. the Egr-1/GGPPS/Erk1/2 pathway is responsible for insulin resistance during hyperinsulinism PMID: 21321112
5. these results reveal a new EGR-1/GGPPS/MAPK signaling pathway that controls cigarette smoke-induced pulmonary inflammation. PMID: 21224049
6. Study suggested that GGPS1 -8188A ins/del polymorphism may confer susceptibility to femoral neck BMD response to bisphosphonate therapy in Korean women. PMID: 20191015
7. crystal structure; it reveals that three dimers join together to form a propeller-bladed hexameric molecule with a mass of approximately 200 kDa PMID: 16698791
8. Farnesyltranstransferase mutations are associated with lonafarnib resistance PMID: 17536018
9. results indicate that the active form of GGPS in the solution is an octamer rather than hexamer or dimer PMID: 17646172
10. Evidence for a non-membrane bound isoform of geranylgeranyl diphosphate synthase 1 in rat. PMID: 8419360

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HGNC: 4249

OMIM: 606982

KEGG: hsa:9453

STRING: 9606.ENSP00000282841

UniGene: Hs.730768