GINS2 Antibody

Code CSB-PA896481ESR2HU
Size US$299 How to order?
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA896481ESR2HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA896481ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) GINS2 Polyclonal antibody
Uniprot No. Q9Y248
Target Names GINS2
Alternative Names DNA replication complex GINS protein PSF2 antibody; GINS complex subunit 2 (Psf2 homolog) antibody; GINS complex subunit 2 antibody; gins2 antibody; HSPC037 antibody; Pfs2 antibody; PSF2 antibody; PSF2_HUMAN antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human DNA replication complex GINS protein PSF2 protein (1-185AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
Gene References into Functions
  1. The authors show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. PMID: 28071757
  2. GINS2 is overexpressed in cervical cancer.GINS2 is a novel indicator of pelvic lymph node metastasis in cervical cancer. PMID: 28405687
  3. silencing of GINS2 in triple negative breast cancer cells caused dramatic decrease of matrix metalloproteinase-9 (MMP9). PMID: 27829549
  4. High GINS2 transcript level is associated with endocrine therapy resistance in beast cancer. PMID: 25348432
  5. On the contrary, after HL60 cells were infected by recombinant adenovirus vector which contained GINS2 gene, we observed that over-expression of GINS2 could promote HL-60 cell proliferation. PMID: 24273454
  6. GINS2 plays an important role in apoptosis and may function via the p38MAPK signaling pathway. PMID: 23589040
  7. Data show that using a 200-nt primed circular DNA substrate, the combined action of DNA polymerase epsilon and the Cdc45/Mcm2-7/GINS (CMG complex) leads to the formation of products >10 kb in length. PMID: 22474384
  8. Data suggest that GINS2 to be associated with the aggressive characteristics of a subgroup of breast cancers in vivo. PMID: 21082043

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Subcellular Location Nucleus. Chromosome.
Protein Families GINS2/PSF2 family
Database Links

HGNC: 24575

OMIM: 610609

KEGG: hsa:51659

STRING: 9606.ENSP00000253462

UniGene: Hs.433180

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