GLDC Antibody

Datasheet
Code CSB-PA328400LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. P23378
Image
  • IHC image of CSB-PA328400LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Glycine dehydrogenase (decarboxylating), mitochondrial protein (868-984AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:500-1:1000
Relevance The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)), GLDC, GCSP
Immunogen Species Homo sapiens (Human)
Research Area Tags & Cell Markers
Target Names GLDC
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).
Involvement in disease Non-ketotic hyperglycinemia (NKH)
Subcellular Location Mitochondrion
Protein Families GcvP family
Database Links

HGNC: 4313

OMIM: 238300

KEGG: hsa:2731

STRING: 9606.ENSP00000370737

UniGene: Hs.584238

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