GLIS3 Antibody, Biotin conjugated

1. Data show that loss of zinc finger protein GLIS3 (GLIS3) causes beta-cell death. PMID: 29992946
2. Data did not show any associations of GLI similar 3 protein (GLIS3) gene polymorphisms rs806052, rs143051164, and rs149840771 with carbohydrate metabolism disorders among patients with maturity onset diabetes of the young (MODY) and type 2 diabetes mellitus (DM2) in Russia. PMID: 29606121
3. Individually the rs7020673 and rs10758593 SNPs are not significantly associated with T1DM but seem to interact in the predisposition for this disease. PMID: 28597135
4. Given the role of GLIS3 in transcriptional activation and repression during embryogenesis, in humans, GLIS3 mutations present with multisystem involvement that also includes renal cystic dysplasia, progressive liver fibrosis and osteopenia. Thyroid findings in GLIS3 patients include thyroid aplasia, diminished colloid with interstitial fibrosis at post-mortem.[review] PMID: 28648506
5. GLIS3 polymorphism is not associated with Dermatomyositis /Polymyositis in the Chinese Han population PMID: 28846454
6. we describe the common facial dysmorphism consisting of bilateral low-set ears, depressed nasal bridge with overhanging columella, elongated, upslanted palpebral fissures, persistent long philtrum with a thin vermilion border of the upper lip in a cohort of seven patients with GLIS3 mutations and report the emergence of a distinct, probably recognizable facial gestalt in this group which evolves with age. PMID: 27148679
7. It may play a role in a number of physiological processes controlled by Glis3. PMID: 26147758
8. New findings with GLIS3 phenotype including craniosynostosis, hiatus hernia, atrial septal defect, splenic cyst, and choanal atresia and confirm further cases with sensorineural deafness and exocrine pancreatic insufficiency. PMID: 26259131
9. analysis of a GLIS3 variant that may have a role in resistance to Japanese type 1 diabetes PMID: 23856252
10. The present data suggest that altered expression of the candidate gene GLIS3 may contribute to both type 1 and 2 type diabetes by favouring beta cell apoptosis PMID: 23737756
11. Alleles of single nucleotide polymorphisms in GLIS3 and ADCY5 may confer risk of type 2 diabetes. PMID: 21949744
12. the associations of GLIS3-rs7034200 and CRY2-rs11605924 with fasting glucose, beta cell function, and type 2 diabetes PMID: 21747906
13. Glis3 interacts with Suppressor of Fused (SUFU) PMID: 21543335
14. results demonstrate a major role for GLIS3 in the development of pancreatic beta cells and the thyroid, eye, liver and kidney PMID: 16715098

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HGNC: 28510

OMIM: 610192

KEGG: hsa:169792

STRING: 9606.ENSP00000371398

UniGene: Hs.162125