GLRX5 Antibody, HRP conjugated

Code CSB-PA769767LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) GLRX5 Polyclonal antibody
Uniprot No. Q86SX6
Target Names GLRX5
Alternative Names C14orf87 antibody; Chromosome 14 open reading frame 87 antibody; FLB4739 antibody; GLRX 5 antibody; Glrx5 antibody; GLRX5_HUMAN antibody; Glutaredoxin 5 homolog antibody; Glutaredoxin related protein 5 antibody; Glutaredoxin-related protein 5 antibody; Glutaredoxin5 antibody; GRX5 antibody; MGC14129 antibody; mitochondrial antibody; Monothiol glutaredoxin-5 antibody; PRO1238 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Glutaredoxin-related protein 5, mitochondrial protein (32-157AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters
Gene References into Functions
  1. GLRX5 rs1007814 showed a statistically marginally significant difference between cases and controls in genotype frequency (case/control: CC 1:6; CT 112:78; TT 752:505, P=0.049361), but no significant differences in allele distribution [odds ratio (OR)=0.852805]In men, we found a minor difference in the genotype frequency (case/control: CC 0:3; CT 72:36; TT 411:280, P=0.037370) and not in allele distribution (OR=1.142857) PMID: 27893590
  2. Patients with GLRX5-associated variant nonketotic hyperglycemia had normal development with childhood-onset spastic paraplegia, spinal lesion, and optic atrophy. PMID: 24334290
  3. crystal structure of GLRX5 revealed a tetrameric organization with the [2Fe-2S] clusters buried in the interior and shielded from the solvent by the conserved beta1-alpha2 loop PMID: 21029046
  4. Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts PMID: 20364084
  5. No GLRX5 mutations were found among sixty CSA probands examined PMID: 19731322
  6. Mutations in GLRX5 is associated with sideroblastic-like microcytic anemia and iron overload PMID: 17485548

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Involvement in disease Anemia, sideroblastic, 3, pyridoxine-refractory (SIDBA3); Spasticity, childhood-onset, with hyperglycinemia (SPAHGC)
Subcellular Location Mitochondrion matrix
Protein Families Glutaredoxin family, Monothiol subfamily
Database Links

HGNC: 20134

OMIM: 609588

KEGG: hsa:51218

STRING: 9606.ENSP00000328570

UniGene: Hs.744943

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