GLRX5 Antibody

Datasheet
Code CSB-PA769767LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q86SX6
Image
  • IHC image of CSB-PA769767LA01HU diluted at 1:500 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA769767LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Glutaredoxin-related protein 5, mitochondrial protein (32-157AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:500-1:1000
Relevance Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5), GLRX5, C14orf87
Immunogen Species Human
Research Area Signal Transduction
Target Names GLRX5
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters
Involvement in disease Anemia, sideroblastic, 3, pyridoxine-refractory (SIDBA3); Spasticity, childhood-onset, with hyperglycinemia (SPAHGC)
Subcellular Location Mitochondrion matrix
Protein Families Glutaredoxin family, Monothiol subfamily
Database Links

HGNC: 20134

OMIM: 609588

KEGG: hsa:51218

STRING: 9606.ENSP00000328570

UniGene: Hs.744943

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