GLRX5 Antibody, Biotin conjugated

Code CSB-PA769767LD01HU
Size US$299
Uniprot No. Q86SX6
Protocols ELISA Protocol
Immunogen Recombinant Human Glutaredoxin-related protein 5, mitochondrial protein (32-157AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5), GLRX5, C14orf87
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names GLRX5
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters
Involvement in disease Anemia, sideroblastic, 3, pyridoxine-refractory (SIDBA3); Spasticity, childhood-onset, with hyperglycinemia (SPAHGC)
Subcellular Location Mitochondrion matrix
Protein Families Glutaredoxin family, Monothiol subfamily
Database Links

HGNC: 20134

OMIM: 609588

KEGG: hsa:51218

STRING: 9606.ENSP00000328570

UniGene: Hs.744943

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