GMEB1 Antibody, Biotin conjugated

Code CSB-PA896751LD01HU
Size US$299 How to order?
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) GMEB1 Polyclonal antibody
Uniprot No. Q9Y692
Target Names GMEB1
Alternative Names DNA binding protein p96PIF antibody; DNA-binding protein p96PIF antibody; Glucocorticoid modulatory element binding protein 1 antibody; Glucocorticoid modulatory element-binding protein 1 antibody; GMEB 1 antibody; GMEB-1 antibody; Gmeb1 antibody; GMEB1_HUMAN antibody; P96PIF antibody; Parvovirus initiation factor p96 antibody; PIF 96 antibody; PIF p96 antibody; PIF96 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Glucocorticoid modulatory element-binding protein 1 protein (2-245AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Gene References into Functions
  1. consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters PMID: 11743720
  2. 1.55 A resolution crystal structure of a central portion of GMEB1, encompassing its SAND domain PMID: 12702733
  3. GMEB1 is capable of binding to the prodomain of caspase-2; findings indicated that GMEB1 might be an endogenous inhibitory protein that selectively interacts with prodomain of caspase-2 to disrupt the autoactivation PMID: 15555560
  4. GMEB1 is an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis PMID: 16497673
  5. GMEB1 effectively attenuated caspase activation and apoptosis caused by these stresses in human neuroblastoma SK-N-MC cells, indicating that it functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress. PMID: 18455874

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Subcellular Location Nucleus. Cytoplasm. Note=May be also cytoplasmic.
Database Links

HGNC: 4370

OMIM: 604409

KEGG: hsa:10691

STRING: 9606.ENSP00000294409

UniGene: Hs.632373

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