GMEB1 Antibody, FITC conjugated

Datasheet

Code	CSB-PA896751LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GMEB1 Polyclonal antibody

Uniprot No.

Q9Y692

Target Names

GMEB1

Alternative Names

DNA binding protein p96PIF antibody; DNA-binding protein p96PIF antibody; Glucocorticoid modulatory element binding protein 1 antibody; Glucocorticoid modulatory element-binding protein 1 antibody; GMEB 1 antibody; GMEB-1 antibody; Gmeb1 antibody; GMEB1_HUMAN antibody; P96PIF antibody; Parvovirus initiation factor p96 antibody; PIF 96 antibody; PIF p96 antibody; PIF96 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Glucocorticoid modulatory element-binding protein 1 protein (2-245AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Gene References into Functions

consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters PMID: 11743720
1.55 A resolution crystal structure of a central portion of GMEB1, encompassing its SAND domain PMID: 12702733
GMEB1 is capable of binding to the prodomain of caspase-2; findings indicated that GMEB1 might be an endogenous inhibitory protein that selectively interacts with prodomain of caspase-2 to disrupt the autoactivation PMID: 15555560
GMEB1 is an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis PMID: 16497673
GMEB1 effectively attenuated caspase activation and apoptosis caused by these stresses in human neuroblastoma SK-N-MC cells, indicating that it functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress. PMID: 18455874

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Subcellular Location

Nucleus. Cytoplasm. Note=May be also cytoplasmic.

Database Links

HGNC: 4370

OMIM: 604409

KEGG: hsa:10691

STRING: 9606.ENSP00000294409

UniGene: Hs.632373

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Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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