GMPPA Antibody

Code CSB-PA009578GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GMPPA
Alternative Names
GDP mannose pyrophosphorylase A antibody; GDP-mannose pyrophosphorylase A antibody; Gmppa antibody; GMPPA_HUMAN antibody; GTP mannose 1 phosphate guanylyltransferase alpha antibody; GTP-mannose-1-phosphate guanylyltransferase alpha antibody; Mannose 1 phosphate guanylyltransferase (GDP) antibody; Mannose-1-phosphate guanyltransferase alpha antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human GMPPA
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.
Gene References into Functions
  1. Based on our findings and the previous report describing patients with an overlapping phenotype, we conclude that this novel variant in GMPPA, identified by exome sequencing in the proband and her affected sister, is the genetic cause of their phenotype and may expand the known phenotype of this recently described glycosylation disorder. PMID: 28574218
  2. GMPPA might serve as a GMPPB regulatory subunit mediating feedback inhibition of GMPPB instead of displaying catalytic enzyme activity itself. PMID: 24035193
Involvement in disease
Alacrima, achalasia, and mental retardation syndrome (AAMR)
Subcellular Location
Cytoplasm. Note=Myc-tagged GMPPA shows a diffuse cytoplasmic and nuclear pattern in transfected COS-7 cells.
Protein Families
Transferase hexapeptide repeat family
Tissue Specificity
Expressed in fibroblasts (at protein level).
Database Links

HGNC: 22923

OMIM: 615495

KEGG: hsa:29926

STRING: 9606.ENSP00000315925

UniGene: Hs.27059

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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