GMPS Antibody

Code CSB-PA009582GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GMPS
Alternative Names
GATD7 antibody; Glutamine amidotransferase antibody; GMP synthase [glutamine hydrolyzing] antibody; GMP synthase [glutamine-hydrolyzing] antibody; GMP synthetase antibody; Gmps antibody; GUAA_HUMAN antibody; Guanine monophosphate synthase antibody; Guanine monphosphate synthetase antibody; Guanosine 5' monophosphate synthase antibody; MLL/GMPS fusion protein antibody; Testicular tissue protein Li 82 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human GMPS
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
Gene References into Functions
  1. Three genes-ATP6V1G1 in 9q32, GMPS in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females PMID: 26890086
  2. Cytoplasmic sequestration of GMPS requires ubiquitylation by TRIM21. PMID: 24462112
Involvement in disease
A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.
Subcellular Location
Cytoplasm.
Database Links

HGNC: 4378

OMIM: 600358

KEGG: hsa:8833

STRING: 9606.ENSP00000419851

UniGene: Hs.591314

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