GNAT1 Antibody

Code CSB-PA002858
Size US$100
  • Western Blot analysis of COLO205 cells using Gα t1 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
CSNBAD3 antibody; GBT1 antibody; GNAT1 antibody; GNAT1_HUMAN antibody; GNATR antibody; guanine nucleotide binding protein (G protein) alpha transducing activity polypeptide 1 antibody; guanine nucleotide binding protein G(T) alpha 1 subunit antibody; Guanine nucleotide-binding protein G(t) subunit alpha-1 antibody; Rod specific transducin antibody; rod-type transducin alpha subunit antibody; Transducin alpha-1 chain antibody; transducin; rod-specific antibody
Raised in
Species Reactivity
Synthesized peptide derived from the Internal region of Human Gα t1.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase.
Gene References into Functions
  1. Our family's ERG showed essentially no rod response, consistent with a Danish GNAT1 pedigree but different from the Nougaret GNAT1 pedigree that shows partial preservation of rod signal. A genetic connection between Complete congenital stationary night blindness and postural orthostatic tachycardia syndrome would be intriguing, but we found no evidence for this. PMID: 30051303
  2. These data suggest that some truncating GNAT1 variants can indeed cause a recessive, mild, late-onset retinal degeneration in human beings rather than just stationary night-blindness as reported previously. PMID: 26472407
  3. Three candidate tumor-suppressor genes, SEMA3B, AXUD1 and GNAT1 may be involved in oral squamous cell carcinoma. PMID: 23292452
  4. These data suggest that a homozygous missense mutation in GNAT1 is associated with autosomal recessive stationary night blindness. PMID: 22190596
  5. Expression of GNAT1 gene is down-regulated or absent in nasopharyngeal carcinoma tissues. PMID: 17222360

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Involvement in disease
Night blindness, congenital stationary, autosomal dominant 3 (CSNBAD3); Night blindness, congenital stationary, 1G (CSNB1G)
Subcellular Location
Cell projection, cilium, photoreceptor outer segment. Membrane; Peripheral membrane protein. Photoreceptor inner segment.
Protein Families
G-alpha family, G(i/o/t/z) subfamily
Tissue Specificity
Rod photoreceptor cells. Predominantly expressed in the retina followed by the ciliary body, iris and retinal pigment epithelium.
Database Links

HGNC: 4393

OMIM: 139330

KEGG: hsa:2779

STRING: 9606.ENSP00000232461

UniGene: Hs.517978

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