GNB5 Antibody

Code CSB-PA092895
Size US$297
  • Western blot analysis of extracts from HepG2 cells, using GNB5 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using GNB5 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GNB5 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
FLJ37457 antibody; FLJ43714 antibody; G protein beta 5 subunit antibody; G protein beta subunit 5L antibody; GB 5 antibody; GB5 antibody; GBB5_HUMAN antibody; Gbeta5 antibody; GNB 5 antibody; GNB5 antibody; Guanine nucleotide binding protein (G protein) beta 5 antibody; Guanine nucleotide binding protein beta 5 antibody; Guanine nucleotide binding protein beta 5 subunit antibody; Guanine nucleotide binding protein beta subunit 5L antibody; Guanine nucleotide binding protein subunit beta 5 antibody; Guanine nucleotide-binding protein subunit beta-5 antibody; Transducin beta chain 5 antibody
Raised in
Species Reactivity
Synthesized peptide derived from internal of Human GNB5.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate.
Gene References into Functions
  1. individuals with loss-of-function GNB5 alleles had more severe symptoms, including substantial developmental delay, speech defects, severe hypotonia, pathological gastro-esophageal reflux, retinal disease, and sinus-node dysfunction, whereas related heterozygotes harboring missense variants presented with a clinically milder phenotype PMID: 27523599
  2. Results suggest that D2R can interact with and stabilize the Gb5 protein, independently of R7 G protein signaling (RGS) proteins. PMID: 25162404
  3. The intrinsic resistance to TRAIL-triggered apoptosis of colon cancer cells is overcome by antagonization of Gbeta5. PMID: 25043307
  4. Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors PMID: 21511947
  5. Gbeta5's function in vision is reviewed. PMID: 20374718
  6. under certain conditions, RGS9 and Gbeta5 may possibly function as betagamma dimer PMID: 15474482
  7. From yeast two hybrid screening with HBX as bait, human guanine nucleotide binding protein beta subunit 5L (GNbeta5) was isolated from the cDNA library constructed in this study as a new hepatitis b X protein-interacting protein. PMID: 16135253
  8. cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP. PMID: 16867977
  9. G-protein beta5 short splice variant isoform is indispensable for outer plexiform layer integrity and normal light responses of the retina in transgenic mice. PMID: 18094259
  10. cytosolic chaperonin complex-dependent mechanism exists for Gbeta5-RGS7 assembly that utilizes the co-chaperone activity of PhLP1 in a unique way. PMID: 19376773

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Involvement in disease
Intellectual developmental disorder with cardiac arrhythmia (IDDCA); Language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia (LADCI)
Subcellular Location
Protein Families
WD repeat G protein beta family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 4401

OMIM: 604447

KEGG: hsa:10681

STRING: 9606.ENSP00000261837

UniGene: Hs.155090

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