GNRH2 Antibody

1. GnRHII expression correlated significantly with poor prognosis in breast cancer patients. PMID: 23287110
2. results suggest GnRH-II-induced laminin receptor precursor expression increases 67-kDa nonintegrin laminin receptor, which appears to interact with laminin in the extracellular matrix to promote MMP-2 expression and enhance ovarian cancer cell invasion PMID: 21193558
3. concluded that GnRHII stimulates PI3K/Akt pathway, and the phosphorylation of glycogen synthase kinase3beta, thereby enhancing the beta-catenin-dependent up-regulation of MT1-MMP production which contributes to ovarian cancer metastasis PMID: 21239435
4. These preliminary data suggest that local GnRH-II may participate in the regulation of ovarian tumor growth in post-menopausal women. PMID: 20018426
5. a novel mechanism in stimulating basal human GnRH-II gene transcription mediated by cooperative actions of multiple regulatory elements within the untranslated first exon of the gene. PMID: 12663744
6. GnRH-II has been identified, together with a 'putative' type II GnRH receptor, both in the central nervous system and in peripheral structures, such as tissues of the reproductive tract (both normal and tumoral). PMID: 14726258
7. GnRH-II did not affect proliferation of normal B-cells alone, and did not alter the proliferative response to IL-2. PMID: 15578334
8. Expression of GnRH2 protein and receptor (GnRHR2) is confirmed in both leiomyoma and patient-matched myometrium. PMID: 17296196
9. these data demonstrate the differential roles of NF-kappaB p65 and RARalpha/RXRalpha, interacting with the same sequence in the promoter of the human GnRH II gene to influence gene expression in a cell-specific manner. PMID: 17451432
10. GnRH II is widely expressed in prostate cancer and is an AR-regulated gene. PMID: 17914092
11. p-CREB, C/EBPbeta, and CBP are recruited to the CRE of the GnRH-II promoter in a temporarily defined manner to enhance its transcription in JEG-3 and OVCAR-3 cells in response to cAMP PMID: 18599546
12. These results provide evidence that EGF is an upstream regulator of the autocrine actions of GnRH-II on the invasive properties of ovarian cancer cells. PMID: 19608641

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HGNC: 4420

OMIM: 602352

KEGG: hsa:2797

STRING: 9606.ENSP00000245983

UniGene: Hs.129715