GPR3 Antibody

Code CSB-PA009800LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA009800LA01HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA009800LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Immunofluorescent analysis of A549 cells using CSB-PA009800LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GPR3 Polyclonal antibody
Uniprot No.
Target Names
GPR3
Alternative Names
GPR3; ACCA; G-protein coupled receptor 3; ACCA orphan receptor
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human G-protein coupled receptor 3 protein (300-330AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GPR3 Antibody (Product code: CSB-PA009800LA01HU) is Non-conjugated. For GPR3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009800LB01HU GPR3 Antibody, HRP conjugated ELISA
FITC CSB-PA009800LC01HU GPR3 Antibody, FITC conjugated
Biotin CSB-PA009800LD01HU GPR3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons and neurite outgrowth. Maintains also meiotic arrest in oocytes.
Gene References into Functions
  1. Results demonstrate that GPR3 signals at the plasma membrane and can be silenced by GRK2/beta-arrestin overexpression. These results also strongly implicate the serine and/or threonine residues in the third intracellular loop in the regulation of GPR3 activity. PMID: 23826079
  2. Gpr3 stimulates Abeta production via interactions with APP and beta-arrestin2. PMID: 24069330
  3. GPR3 is a key factor in the regulation of the nervous system and follicle development.[review] PMID: 23732663
  4. GPR3 is expressed in the ovary and testes, and is necessary for the regulation of meiosis in mouse. PMID: 15591206
  5. Mutations in GPR3 are not a common cause of premature ovarian failure in Chinese women. PMID: 20158988
  6. control of gene expression in vascular endothelial cells in the presence of fluid shear stress and classifies it as a sphingosine 1-phosphate receptor. PMID: 12649592
  7. We conclude that perturbations in GPR3 are not a common explanation for POF in this population. PMID: 17953967

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.
Database Links

HGNC: 4484

OMIM: 600241

KEGG: hsa:2827

STRING: 9606.ENSP00000363136

UniGene: Hs.66542

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