GPT2 Antibody, HRP conjugated

1. The GPT2 gene demonstrates increasing expression in brain in the early postnatal period, and GPT2 protein localizes to mitochondria. Akin to the human phenotype, Gpt2-null mice exhibit reduced brain growth. Through metabolomics and direct isotope tracing experiments, we find a number of metabolic abnormalities associated with loss of Gpt2 PMID: 27601654
2. Recessively inherited loss of function GPT2 mutations are a novel cause of intellectual disability. PMID: 25758935
3. ATF4 silencing prevented the activating effect of histidinol and tunicamycin on ATF4 and ALT2 expression. Our findings point to ALT2 as an enzyme involved in the metabolic adaptation of the cell to stress PMID: 24418603
4. expression of GPT2 especially in muscle and fat, suggests a unique and previously unrecognized role of this gene product in glucose, amino acid, and fatty acid metabolism and homeostasis. PMID: 11863375
5. The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects. PMID: 17109502
6. Elevation of liver enzymes and hepatic insulin resistance as reflected by fasting insulin occur in the early stages of insulin resistance and highlight the central role of the liver in insulin resistance in the general population. PMID: 17596883
7. A clinical method for selective measurement of ALT1 and 2 in human plasma is described. PMID: 19360321

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HGNC: 18062

OMIM: 138210

KEGG: hsa:84706

STRING: 9606.ENSP00000345282

UniGene: Hs.460693