GRAMD4 Antibody

Code CSB-PA764225LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Mouse brain tissue
    All lanes: GRAMD4 antibody at 3.4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 67, 11 kDa
    Observed band size: 67 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA764225LA01HU at dilution of 1:100

  • Western Blot
    Positive WB detected in: MCF-7 whole cell lysate
    All lanes: GRAMD4 antibody at 5µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 67, 11 kDa
    Observed band size: 67 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GRAMD4 Polyclonal antibody
Uniprot No.
Target Names
GRAMD4
Alternative Names
GRAMD4; DIP; KIAA0767; GRAM domain-containing protein 4; Death-inducing protein
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human GRAM domain-containing protein 4 protein (23-161AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GRAMD4 Antibody (Product code: CSB-PA764225LA01HU) is Non-conjugated. For GRAMD4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA764225LB01HU GRAMD4 Antibody, HRP conjugated ELISA
FITC CSB-PA764225LC01HU GRAMD4 Antibody, FITC conjugated
Biotin CSB-PA764225LD01HU GRAMD4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response.
Gene References into Functions
  1. The expression of GRAMD4 is up-regulated in hepatocellular carcinoma cell(HCC cell) lines and HCC tissues, and the increased expression is correlated with the clinicopathological characteristics of HCC. PMID: 23388340
  2. GRAMD4 induces changes in Bcl-2 and Bax protein levels PMID: 21127500
  3. localizes to the mitochondria, upregulated following E2F1 induction PMID: 15565177
  4. DIP induces p53-independent caspase-dependent and -independent apoptosis. DIP is localized in the mitochondria. DIP accumulates upon E2F1 activation. PMID: 15565177
Subcellular Location
Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed in lung and in primary lung squamous cell carcinoma (LSCC).
Database Links

HGNC: 29113

OMIM: 613691

KEGG: hsa:23151

STRING: 9606.ENSP00000354313

UniGene: Hs.475150

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