GRAP Antibody

Datasheet

Code	CSB-PA618789LA01HU
Size	US$166
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Image	IHC image of CSB-PA618789LA01HU diluted at 1:30 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GRAP Polyclonal antibody

Uniprot No.

Q13588

Target Names

GRAP

Alternative Names

Grap antibody; GRAP_HUMAN antibody; GRB2 related adaptor protein antibody; GRB2-related adapter protein antibody; Growth factor receptor bound protein 2 related adaptor protein antibody; MGC64880 antibody; OTTHUMP00000065766 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human GRB2-related adapter protein (1-217AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The GRAP Antibody (Product code: CSB-PA618789LA01HU) is Non-conjugated. For GRAP Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA618789LB01HU	GRAP Antibody, HRP conjugated	ELISA
FITC	CSB-PA618789LC01HU	GRAP Antibody, FITC conjugated
Biotin	CSB-PA618789LD01HU	GRAP Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing.

Gene References into Functions

Findings suggest that the miR-654-5p/GRAP/Ras/Erk signaling pathway in OSCC cells might contribute to the underlying mechanism through which miR-654-5p participates in the regulation of OSCC progression. PMID: 29364705
Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from fibrotic kidneys from diabetic patients, and subsequently confirmed as a novel component of TGF-beta signaling in cultured human renal tubule cells. PMID: 19836472
Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome. PMID: 15174222
Our findings define a pathway involving CD28 binding to Grb-2 and its co-operativity with Vav1 in the regulation of T-cell co-stimulation. PMID: 18295596

Subcellular Location

Membrane; Peripheral membrane protein. Cell junction, synapse.

Protein Families

GRB2/sem-5/DRK family

Database Links

HGNC: 4562

OMIM: 604330

KEGG: hsa:10750

STRING: 9606.ENSP00000284154

UniGene: Hs.567416

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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