GRHL1 Antibody, HRP conjugated

1. Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3, which may be regulated by miR-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 gene or functioning of encoded protein PMID: 29301499
2. All of these processes involve epithelial-mesencyhmal transition (EMT), MET or a sequence of both, suggesting that the GRHL factors((GRHL1, GRHL2 and GRHL3), could potentially affect tumor initiation and progression via EMT PMID: 28714958
3. it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1. PMID: 27035558
4. Grhl1 deficiency affects inner ear development in zebrafish. PMID: 25896282
5. GRHL1, GRHL2, and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review] PMID: 26069269
6. Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. PMID: 25406394
7. A significant role for HDAC3 in the MYCN-mediated repression of GRHL1. PMID: 24419085
8. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity. PMID: 24375798
9. LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter activity. PMID: 18004979
10. Includes a comparison to TFCP2L2, the GRHL1 protein. PMID: 12393799

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HGNC: 17923

OMIM: 609786

KEGG: hsa:29841

STRING: 9606.ENSP00000324693

UniGene: Hs.418493