GRIK4 Antibody

1. the GRIK4 polymorphisms genotypes were distributed as follows: rs79526501: CC696: 16, CG302: 274, GG31: 35; rs11218016: CC455: 483, CT473: 436, TT101: 108; and rs6589847: AA32: 29, AG307: 314, GG690: 686. However, there was no significant difference in allelic or genotypic frequency distributions between patients and controls. We did not find any significant association between GRIK4 polymorphisms and schizophrenia. PMID: 28658089
2. Results firstly indicated that rs56275759 of GRIK4 gene might be associated with major depressive disorder in Chinese Han population. PMID: 28583584
3. This study showed the lower GluK4 mRNA levels in pregnant women. PMID: 28284346
4. Data suggest the involvement of glutamate receptor, ionotropic, kainate 4 protein (GRIK4) in treatment-resistant depression (TRD) and in the risk of developing psychotic symptoms during depressive episodes. PMID: 26139080
5. Subjects possessing the C allele or CC genotype of the GRIK4 polymorphism rs1954787 are more likely to respond to antidepressant treatment. PMID: 25303296
6. The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells. PMID: 22052594
7. Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation and immunoglobulin production. PMID: 21215464
8. The GRIK4 single nucleotide polymorphism (rs12800734) shows a strong association with disease remission in antidepressant treatment. PMID: 19924111
9. Cytogenetic and genetic findings provide molecular evidence for common etiologies for schizophrenia and and bipolar disorder and further support the 'glutamate hypothesis' of psychotic illness. PMID: 16819533
10. An insertion/deletion (indel) variant in the 3' untranslated region (3'UTR) of the GRIK4 gene in subjects carrying the protective bipolar disorder haplotype was found. PMID: 18824690
11. This report provides the first evidence that genetic variation in the GRIK4 gene modulates hippocampal function. PMID: 19384319

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HGNC: 4582

OMIM: 600282

KEGG: hsa:2900

STRING: 9606.ENSP00000404063

UniGene: Hs.538738