GRIN3B Antibody

Code CSB-PA009917ESR1HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GRIN3B Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
GluN3B antibody; Glutamate [NMDA] receptor subunit 3B antibody; Glutamate receptor ionotropic N methyl D aspartate 3B antibody; Glutamate receptor ionotropic NMDA 3B antibody; GRIN3B antibody; N-methyl-D-aspartate receptor subtype 3B antibody; NMD3B_HUMAN antibody; NMDA receptor subunit 3B antibody; NMDA type glutamate receptor subunit NR3B antibody; NMDAR3B antibody; NR3B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Glutamate receptor ionotropic, NMDA 3B protein (180-410AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
Gene References into Functions
  1. GRIN3B missense mutation is an inherited risk factor for schizophrenia. PMID: 28132660
  2. Authors investigated the significance of a common human genetic variation of the NMDAR NR3B subunit PMID: 25768306
  3. Rs2240158 of GRIN3B was significantly associated with mismatch negativity in healthy subjects. PMID: 24814139
  4. our findings suggest that the over-expression of NR3B subunit of NMDA receptor is a long lasting result of chronic opioid abuse. PMID: 20153313
  5. These observations suggest that the genetic variation of the NR3B subunit of the NMDA receptor is not a risk factor for Alzheimer's dis pathogenesis PMID: 20016182
  6. NR3B mRNA expression in the human hippocampal formation (CA1-CA4 and dentate gyrus) and adjacent neocortex may have implications for understanding the role of NMDA receptors for physiological and pathological processes in these forebrain regions. PMID: 15722182
  7. cross-talk between NR3B and NR4A receptors is a mechanism modulating the transcriptional activities of these orphan nuclear receptors PMID: 17543277
  8. We tested whether genetic dysfunction of GRIN3B is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). PMID: 17687115

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.
Protein Families
Glutamate-gated ion channel (TC 1.A.10.1) family, NR3B/GRIN3B subfamily
Database Links

HGNC: 16768

OMIM: 606651

KEGG: hsa:116444

STRING: 9606.ENSP00000234389

UniGene: Hs.660378

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