GRIN3B Antibody

Datasheet

Code	CSB-PA009917ESR1HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GRIN3B Polyclonal antibody

Uniprot No.

O60391

Target Names

GRIN3B

Alternative Names

GluN3B antibody; Glutamate [NMDA] receptor subunit 3B antibody; Glutamate receptor ionotropic N methyl D aspartate 3B antibody; Glutamate receptor ionotropic NMDA 3B antibody; GRIN3B antibody; N-methyl-D-aspartate receptor subtype 3B antibody; NMD3B_HUMAN antibody; NMDA receptor subunit 3B antibody; NMDA type glutamate receptor subunit NR3B antibody; NMDAR3B antibody; NR3B antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Glutamate receptor ionotropic, NMDA 3B protein (180-410AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

Gene References into Functions

GRIN3B missense mutation is an inherited risk factor for schizophrenia. PMID: 28132660
Authors investigated the significance of a common human genetic variation of the NMDAR NR3B subunit PMID: 25768306
Rs2240158 of GRIN3B was significantly associated with mismatch negativity in healthy subjects. PMID: 24814139
our findings suggest that the over-expression of NR3B subunit of NMDA receptor is a long lasting result of chronic opioid abuse. PMID: 20153313
These observations suggest that the genetic variation of the NR3B subunit of the NMDA receptor is not a risk factor for Alzheimer's dis pathogenesis PMID: 20016182
NR3B mRNA expression in the human hippocampal formation (CA1-CA4 and dentate gyrus) and adjacent neocortex may have implications for understanding the role of NMDA receptors for physiological and pathological processes in these forebrain regions. PMID: 15722182
cross-talk between NR3B and NR4A receptors is a mechanism modulating the transcriptional activities of these orphan nuclear receptors PMID: 17543277
We tested whether genetic dysfunction of GRIN3B is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). PMID: 17687115

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.

Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family, NR3B/GRIN3B subfamily

Database Links

HGNC: 16768

OMIM: 606651

KEGG: hsa:116444

STRING: 9606.ENSP00000234389

UniGene: Hs.660378

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

cAMP signaling pathway Glutamatergic synapse

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