GRM8 Antibody

Datasheet

Code	CSB-PA232728
Size	US$297
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Image	Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR8 antibody. Western blot analysis of extracts from mouse brain, using GluR8 antibody. Western blot analysis of extracts from k562 cells (Lane 2), using mGluR8 antiobdy. The lane on the left is treated with synthesized peptide.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GRM8 Polyclonal antibody

Uniprot No.

O00222

Target Names

GRM8

Alternative Names

FLJ41058 antibody; GLUR8 antibody; Glutamate receptor metabotropic 8 antibody; GPRC1H antibody; GRM8 antibody; GRM8_HUMAN antibody; Metabotropic glutamate receptor 8 antibody; MGC126724 antibody; mGlu8 antibody; mGluR8 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from Human GluR8.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene References into Functions

This study showed that GRM8 was nominally associated (p < 0.05) with both delta measures (energy and intertrial phase coherence). PMID: 27871913
These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence. PMID: 25978827
Genome wide association study and meta-analysis results detected rs6951643, a GRM8 genetic variant as suggestive marker for sporadic Creutzfeldt-Jakob disease risk mapping outside the PRNP region. PMID: 25918841
propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1, and GRM8). PMID: 24821406
The GRM8 gene might play an important role in the pathogenesis of schizophrenia. PMID: 25588301
Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain PMID: 23420844
Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP. PMID: 21493956
Pias1 binds to and sumoylates metabotropic glutamate receptor 8 PMID: 16144832
GRM8 genes are likely involved in the pathogenesis of autistic disorder. PMID: 17955477
Association of suingle nucleotide polymorphisms in GRM8 with theta power of event-related oscillations and alcohol dependence are reported. PMID: 18618593

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 3 family

Database Links

HGNC: 4600

OMIM: 601116

KEGG: hsa:2918

STRING: 9606.ENSP00000344173

UniGene: Hs.449625

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Oxidative Phosphorylation Phospholipase D signaling pathway Glutamatergic synapse G protein coupled receptor signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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