GUF1 Antibody

Code CSB-PA040226
Size US$100
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Product Details

Uniprot No.
Target Names
GUF1
Alternative Names
GUF1 antibody; Translation factor GUF1 antibody; mitochondrial antibody; EC 3.6.5.- antibody; Elongation factor 4 homolog antibody; EF-4 antibody; GTPase GUF1 antibody; Ribosomal back-translocase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human GUF1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Gene References into Functions
  1. Homozygous variant in the GUF1 gene identified in the three siblings with West syndrome. PMID: 26486472
  2. The structure provides insights into the tRNA-remodeling function of EF-4 on the ribosome and suggests that the displacement of the CCA-end of the A-site tRNA away from the peptidyl transferase center (PTC) is functionally significant. PMID: 27092003
Involvement in disease
Epileptic encephalopathy, early infantile, 40 (EIEE40)
Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein Families
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, LepA subfamily
Database Links

HGNC: 25799

OMIM: 617064

KEGG: hsa:60558

STRING: 9606.ENSP00000281543

UniGene: Hs.546419

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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