GUF1 Antibody

Code CSB-PA010058GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GUF1
Alternative Names
GUF1 antibody; Translation factor GUF1 antibody; mitochondrial antibody; EC 3.6.5.- antibody; Elongation factor 4 homolog antibody; EF-4 antibody; GTPase GUF1 antibody; Ribosomal back-translocase antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human GUF1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Gene References into Functions
  1. Homozygous variant in the GUF1 gene identified in the three siblings with West syndrome. PMID: 26486472
  2. The structure provides insights into the tRNA-remodeling function of EF-4 on the ribosome and suggests that the displacement of the CCA-end of the A-site tRNA away from the peptidyl transferase center (PTC) is functionally significant. PMID: 27092003
Involvement in disease
Epileptic encephalopathy, early infantile, 40 (EIEE40)
Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein Families
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, LepA subfamily
Database Links

HGNC: 25799

OMIM: 617064

KEGG: hsa:60558

STRING: 9606.ENSP00000281543

UniGene: Hs.546419

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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